课题基金 / 基金详情

COVID-19 GenOMICC-GENOMICS ENGLAND PARTNERSHIP

COVID-19 GenOMICC-GENOMICS ENGLAND PARTNERSHIP
COVID-19 GenOMICC-GENOMICS 英国合作伙伴关系
批准号:
MC_PC_20004
负责人:
John Kenneth Baillie
金额:
$191.13万
依托单位:
依托单位国家:
英国
项目类别:
Intramural
财政年份:
2020
资助国家:
英国
项目状态:
已结题
起止时间:
2020 至 --

项目摘要

项目成果

John Kenneth Baillie的其他基金

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相关文献

中文摘要
翻译
数以千计的冠状病毒重病患者将接受基因密码研究,以帮助科学家了解一个人的基因是否会影响他们对病毒的易感性。NHS将进行一项新的重大人类全基因组测序研究,涉及目前或以前在重症监护病房感染冠状病毒的多达20,000人,以及15,000名有轻度或中度症状的人。基因组学英国公司正在与GenOMICC财团、Illumina和NHS合作发起这项研究活动,这项研究将覆盖英国170个重症监护病房的患者。该项目得到了英国基因组学公司、英国研究与创新公司、卫生与社会保健部和国家卫生研究所的支持。Illumina将对全部35,000个基因组进行测序,并通过实物捐助分担部分成本。这项研究由爱丁堡大学和多家NHS医院推动,将探索冠状病毒对患者的各种影响,通过识别风险最高的患者来支持治疗方法的搜索,并帮助将新疗法快速进入临床试验。
英文摘要
Thousands of patients severely ill with coronavirus will have their genetic code studied to help scientists understand whether a person’s genetics may influence their susceptibility to the virus. A major new human whole genome sequencing study will take place across the NHS, involving up to 20,000 people currently or previously in an intensive care unit with coronavirus, as well as 15,000 individuals who have mild or moderate symptoms. Genomics England, is partnering with the GenOMICC consortium, Illumina and the NHS to launch the research drive, which will reach patients in 170 intensive care units throughout the UK. The project is backed by Genomics England, UK Research and Innovation, the Department of Health and Social Care and the National Institute for Health Research. Illumina will sequence all 35,000 genomes and share some of the cost via an in-kind contribution. The study, facilitated by the University of Edinburgh and multiple NHS hospitals, will explore the varied effects coronavirus has on patients, supporting the search for treatments by identifying those most at risk and helping to fast-track new therapies into clinical trials.
期刊论文(10)
专著(0)
科研奖励(0)
会议论文
CAGE sequencing reveals CFTR-dependent dysregulation of type I IFN signaling in activated cystic fibrosis macrophages.
CAGE测序揭示了激活的囊性纤维化巨噬细胞中I型IFN信号传导的CFTR依赖性失调。
DOI: 10.1126/sciadv.adg5128
发表时间: 2023-05-26
期刊: Science advances
影响因子: 13.6
作者: [Gillan JL, Chokshi M, Hardisty GR, Clohisey Hendry S, Prasca-Chamorro D, Robinson NJ, Lasota B, Clark R, Murphy L, Whyte MKB, Baillie JK, Davidson DJ, Bao G, Gray RD]
通讯作者: Gray RD
DOI: 10.1007/s00439-021-02397-7
发表时间: 2022-01
期刊: Human genetics
影响因子: 5.3
作者: [Fallerini C, Picchiotti N, Baldassarri M, Zguro K, Daga S, Fava F, Benetti E, Amitrano S, Bruttini M, Palmieri M, Croci S, Lista M, Beligni G, Valentino F, Meloni I, Tanfoni M, Minnai F, Colombo F, Cabri E, Fratelli M, Gabbi C, Mantovani S, Frullanti E, Gori M, Crawley FP, Butler-Laporte G, Richards B, Zeberg H, Lipcsey M, Hultström M, Ludwig KU, Schulte EC, Pairo-Castineira E, Baillie JK, Schmidt A, Frithiof R, WES/WGS Working Group Within the HGI, GenOMICC Consortium, GEN-COVID Multicenter Study, Mari F, Renieri A, Furini S]
通讯作者: Furini S
DOI: 10.1016/s2589-7500(23)00051-1
发表时间: 2023-07
期刊: LANCET DIGITAL HEALTH
影响因子: 30.8
作者: [Docherty, Annemarie B., Farrell, James, Thorpe, Mathew, Egan, Conor, Dunn, Sarah, Norman, Lisa, Shaw, Catherine A., Law, Andrew, Leeming, Gary, Norris, Lucy, Brooks, Andrew, Prodan, Bianca, MacLeod, Ruairidh, Baxter, Robert, Morris, Carole, Rennie, Diane, Oosthuyzen, Wilna, Semple, Malcolm G., Baillie, J. Kenneth, Pius, Riinu, Seth, Sohan, Harrison, Ewen M., Lone, Nazir, I]
通讯作者: Lone, Nazir, I
DOI: 10.1016/j.retram.2022.103333
发表时间: 2022-05
期刊: Current research in translational medicine
影响因子: 4.1
作者: [David A, Parkinson N, Peacock TP, Pairo-Castineira E, Khanna T, Cobat A, Tenesa A, Sancho-Shimizu V, GenOMICC Consortium, ISARIC4C Investigators, Casanova JL, Abel L, Barclay WS, Baillie JK, Sternberg MJ]
通讯作者: Sternberg MJ
共 7 条
    The Edinburgh Molecular Mechanisms Cluster
    • 批准号:
      MR/Y030877/1
    • 项目类别:
      Research Grant
    • 资助金额:
      $541.62万
    • 财政年份:
      2024
    • 负责人:
      John Kenneth Baillie
    • 依托单位:
    ISARIC CCP activation for acute hepatitis of unknown cause
    • 批准号:
      MR/X010252/1
    • 项目类别:
      Research Grant
    • 资助金额:
      $126.14万
    • 财政年份:
      2022
    • 负责人:
      John Kenneth Baillie
    • 依托单位:
    Interim support for ISARIC4C Clinical Characterisation Protocol (CCP) activation for acute severe hepatitis in children of unknown cause
    • 批准号:
      MC_PC_22004
    • 项目类别:
      Intramural
    • 资助金额:
      $9.46万
    • 财政年份:
      2022
    • 负责人:
      John Kenneth Baillie
    • 依托单位:
    ISARIC - Coronavirus Clinical Characterisation Consortium (ISARIC-4C)
    • 批准号:
      MC_PC_19059
    • 项目类别:
      Intramural
    • 资助金额:
      $625.5万
    • 财政年份:
      2020
    • 负责人:
      John Kenneth Baillie
    • 依托单位:
    国内基金
    海外基金
    1H/19F多核MRI术中可视化免疫抑制巨噬细胞定位脑胶质瘤浸润边界
    芽孢杆菌TR19-1对魔芋腐皮镰刀菌拮抗机理研究
    ATPIF1调节线粒体膜电位影响靶向CD19 CAR-T细胞抗肿瘤活性的作用及机制
    • 批准号:
      2026JJ80001
    • 项目类别:
      省市级项目
    • 资助金额:
      --
    • 批准年份:
      2026
    • 负责人:
      钟根深
    • 依托单位:
    CD19/BCMA双靶向CAR-NK细胞治疗难治性SLE:作用机制与临床前转化研究
    • 批准号:
      2026JJ81339
    • 项目类别:
      省市级项目
    • 资助金额:
      --
    • 批准年份:
      2026
    • 负责人:
      谢希
    • 依托单位: