Structural biology and imaging platform

高分辨率成像技术是帮助我们了解病毒如何致病的强大工具。结构生物学和成像平台提供了访问最先进的工具的途径，以便在专家技术人员的支持下可视化病毒过程。该平台支持跨尺度的病毒行为研究，从解析组成病毒粒子(病毒子)的分子的原子结构及其如何与受感染宿主的原子结构相互作用，到成像受感染组织中的病毒。CVR中的研究人员将使用这些工具来了解例如，病毒如何附着和进入宿主细胞，执行这一重要功能的分子如何进化以避免宿主免疫反应；细胞如何对病毒的存在做出反应，例如通过制造特殊结构来包裹病毒基因组并阻止其表达，或关闭病毒需要复制的宿主过程；病毒群在穿过肺等器官时如何相互作用；以及病毒如何组装和离开受感染的细胞。

High-resolution imaging technologies are powerful tools to help us understand how viruses cause disease. The structural biology and imaging platform provides access to state-of-the-art tools to allow visualisation of viral processes, supported by expert technologists. The platform supports the investigation of virus behaviour across scales ranging from resolving the atomic structure of the molecules that virus particles (virions) are made up of and how they interact with those of the infected host, through to imaging viruses in infected tissues.These tools will be used by investigators in the CVR to understand e.g., how viruses can attach to and enter host cells, and how the molecules that perform this vital function evolve to avoid the host immune response; how cells can respond to the presence of a virus by for example making special structures to wrap up the viral genome and stop it expressing, or shutting down host processes that the virus needs to replicate; how populations of viruses can interact with each other as they move through an organ such as the lung; and how viruses assemble and leave an infected cell.