Respiratory infections

呼吸道感染：呼吸道病毒的流行病学、进化和生态学Pablo Murcia博士，首席研究员，与Louise Matthews博士（格拉斯哥大学生物多样性、动物健康和比较医学研究所）合作；Rory Gunson博士（西苏格兰专家病毒学中心）；吉姆·麦克梅纳明博士（苏格兰卫生保护部门）；Robert Gifford博士（mrc -格拉斯哥大学病毒研究中心）。呼吸道感染是人类最常见的疾病，其中很大一部分是由病毒性病原体引起的，包括甲型和乙型流感病毒、呼吸道合胞病毒、人偏肺病毒、冠状病毒、鼻病毒、腺病毒和副流感病毒。从生态学的角度来看，呼吸道可以看作是上述病毒共生的生态系统。值得注意的是，呼吸道病毒传统上是孤立研究的，这种方法没有捕捉到普遍存在的病毒之间的相互作用，这些病毒可能在疾病的出现和传播中发挥作用。在这里，我们将研究呼吸道病毒作为一个群体，以了解病毒-病毒相互作用如何影响它们的进化和流行病学。为此，我们将首先检查格拉斯哥人口中病毒性呼吸道感染的流行病学。此外，我们将对来自患者的大量呼吸道病毒的基因组进行测序，以便将病毒遗传组成的变化与病毒循环模式联系起来。这项工作的结果将对公共卫生产生深远的影响，从改进流行病预测到设计针对人类最常见病原体的新型疫苗接种策略。

Respiratory Infections: Epidemiology, evolution and ecology of respiratory virusesDr Pablo Murcia, Lead Investigator, in collaboration with Dr Louise Matthews (Institute of Biodiversity Animal Health and Comparative Medicine, University of Glasgow); Dr Rory Gunson (West of Scotland Specialist Virology Centre); Dr Jim McMenamin (Health Protection Scotland); Dr Robert Gifford, (MRC-University of Glasgow Centre for Virus Research).Respiratory infections are the most common disease of humans and a large proportion of them is caused by viral pathogens that include influenza A and B viruses, respiratory syncytial virus, human metapneumovirus, coronaviruses, rhinoviruses, adenoviruses and parainfluenzaviruses. From an ecological perspective, the respiratory tract could be considered the ecosystem that the aforementioned viruses cohabitate. Notably, respiratory viruses have been traditionally studied in isolation, an approach that does not capture the interactions among viruses that commonly exist and are likely to play a role in disease presentation and spread. Here we will study respiratory viruses as a group in order to understand how virus-virus interactions impact on their evolution and epidemiology. To this end we will first examine the epidemiology of viral respiratory infections in the Glasgow population. Further we will sequencethe genomes of a large number of respiratory viruses derived from patients in order to link changes in virus genetic composition with patterns of virus circulation. Results from this work will have profound public health implications, from improved forecasting of epidemics to the design of novel vaccination strategies against the most common pathogens of humans.