Determining the contribution of peripheral immune complement signalling in the progression of motor neuron disease

运动神经元病（MND）是一种使人衰弱和致命的神经退行性疾病，目前尚无有效的治疗方法。我们认为过度活跃的免疫系统是导致这种疾病的主要因素。为了验证这一点，我们将检查MND患者的免疫途径，并将在MND动物模型中测试一种新的免疫调节药物。我们希望找到新的治疗途径来减缓疾病进展，并改善被诊断为MND的患者的生活质量。

Motor neuron disease (MND) is a debilitating and lethal neurodegenerative disease, which has no effective treatment. We propose that an overactive immune system is a major contributing factor in this disease. To test this, we will examine immune pathways in patients suffering from MND, and will test a novel immune-modulatory drug in animal models of MND. We hope to identify new therapeutic avenues to slow disease progression, and improve the quality of life in patients diagnosed with MND.