THE EFFECTS OF COCAINE ON DOPAMINE UPTAKE IN THE RAT BRAIN

大脑中的多巴胺能神经元被认为在 精神分裂症的病因学 精神分裂症被认为是由于 大脑某些区域的多巴胺失衡 毒品可卡因 增强多巴胺在大脑中的作用。 吸食可卡因的人 在高剂量的一段较长的时间可能会遭受的症状， 长期的抑郁和冷漠类似的阴性症状， 精神分裂症 类似地，在大鼠中，重复给予高剂量的 剂量的可卡因可导致自发活动减少， 低剂量兴奋剂药物常见的致敏状态 挑战. 在早期的研究中，我们评估了可卡因 给药对大鼠三个脑区中多巴胺摄取的影响。 这些数据将发表在1994年7月的《联合国日刊》上。 药理学和实验治疗学。 我们发现慢性 可卡因给药导致摄入显著减少， 多巴胺进入额叶皮层（49%），无显着差异 在丘脑或纹状体中。 基线自发活动为 在长期使用可卡因治疗的大鼠中显著降低（29%） 与盐水处理的大鼠相比。 一剂可卡因或者- 安非他明产生了类似的增加运动活动高于 在盐水和可卡因处理的大鼠中的相应基线值， 表明行为敏感化没有发生。 我们有 继续我们在这一领域的工作，提出了一个问题，“缺乏 行为敏感化与多巴胺摄取减少有关 大脑额叶皮层"

Dopaminergic neurons in the brain are thought to play an important role in the etiology of schizophrenia. Schizophrenia is thought to be due to an imbalance of dopamine in certain brain areas. The drug cocaine enhances the action of dopamine in the brain. Humans who take cocaine in high doses for a prolonged period of time may suffer symptoms of prolonged depression and apathy similar to the negative symptoms seen in schizophrenics. Similarly, in rats the repeated administration of high doses of cocaine can produce a decrease in locomotor activity and a lack of the usual sensitization state seen with lower dose stimulant drug challenge. In earlier studies, we evaluated the effects of cocaine administration on the uptake of dopamine in three brain areas of the rat. These data will be published in the July 1994 issue of the Journal of Pharmacology and Experimental Therapeutics. We found that chronic cocaine administration produced a significant decrease in the uptake of dopamine into the frontal cortex (49%) with no significant differences in the nucleus accumbens or striatum. Baseline locomotor activity was significantly lower (29%) in rats treated chronically with cocaine compared with saline-treated rats. A challenge dose of cocaine or d- amphetamine produced similar increases in locomotor activity above the corresponding baseline values in both saline- and cocaine-treated rats, indicating that behavioral sensitization had not occurred. We have continued our work in this area by asking the question "does the lack of behavioral sensitization correlate with the decrease of dopamine uptake in the frontal cortex?"