DOPAMINE-INDUCED NEUROTOXICITY IN A CATECHOLAMINERGIC CELL LINE
DOPAMINE-INDUCED NEUROTOXICITY IN A CATECHOLAMINERGIC CELL LINE
批准号:
5203799
负责人:
J M MASSERANO
金额:
$0.0万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至
中文摘要
大脑中过度活跃的多巴胺能神经元被认为起到了作用
英文摘要
Overactive dopaminergic neurons in the brain are thought to play an
important role in the etiology of schizophrenia. It has been
hypothesized that prolonged exposure of catecholamine neurons to
excessive levels of dopamine or the oxidative metabolites of dopamine may
produce neuronal damage, cell death, and be partially responsible for
some of the negative symptoms of schizophrenia. Catecholamines have been
shown to be neurotoxic to norepinephrine and dopamine neurons in primary
culture (J Neurosci Res 26:428, 1990; J Pharmacol Exp Ther 262:1274,
1992). We are evaluating the neurotoxic effects of dopamine by using a
clonal cell line developed by Chikaraishi and co-workers (J Neurosci
13:1280, 1993). This cell line was derived from a tyrosine hydroxylase
positive tumor obtained from the CNS of transgenic mice carrying the SV
40 T antigen oncogene under the transcriptional control of the rat
tyrosine hydroxylase gene. We found that incubation of CATH.a cells with
dopamine produced dose-dependent cell death, with the highest
concentration of dopamine (500 mM) killing 80% of the cells relative to
untreated cells. This cell death was found to be due to apoptosis as
evaluated by DNA fragmentation using gel-electrophoresis techniques and
flow cytometry analysis. Apoptosis appeared to be produced by dopamine
autoxidation, since intracellular peroxides increase after dopamine
treatment, and cell death was inhibited by catalase. Bcl-2 levels
decrease in a dose dependent manner in response to dopamine. These
findings suggest that the oxidative products of dopamine cause
neurotoxicity and can regulate bcl-2 levels. The regulation of bcl-2 may
be important in deterring the neurodegeneration of dopamine neurons in
Parkinson's disease.
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THE EFFECTS OF COCAINE ON DOPAMINE UPTAKE IN THE RAT BRAIN
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批准号:3781476
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J M MASSERANO
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依托单位:
REGULATION OF SECOND MESSENGER SYSTEMS IN EBV-TRANSFORMED B-CELL LINES
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批准号:3781514
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J M MASSERANO
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依托单位:
THE EFFECTS OF COCAINE ON TYROSINE HYDROXYLASE ACTIVITY IN THE RAT BRAIN
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批准号:3759485
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J M MASSERANO
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依托单位:
DOPAMINE INDUCED NEUROTOXICITY IN A CATECHOLAMINERGIC CELL LINE
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批准号:6162909
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J M MASSERANO
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依托单位:
DOPAMINE INDUCED NEUROTOXICITY IN A CATECHOLAMINERGIC CELL LINE
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批准号:6111174
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J M MASSERANO
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依托单位:
DOPAMINE-INDUCED NEUROTOXICITY IN A CATECHOLAMINERGIC CELL LINE
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批准号:2578795
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J M MASSERANO
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依托单位:
DOPAMINE-INDUCED NEUROTOXICITY IN A CATECHOLAMINERGIC CELL LINE
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批准号:3781515
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J M MASSERANO
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依托单位:
DOPAMINE-INDUCED NEUROTOXICITY IN A CATECHOLAMINERGIC CELL LINE
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批准号:3759521
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J M MASSERANO
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依托单位:
THE EFFECTS OF COCAINE ON TYROSINE HYDROXYLASE ACTIVITY IN THE RAT BRAIN
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批准号:5203770
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J M MASSERANO
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依托单位:
REGULATION OF SECOND MESSENGER SYSTEMS IN EBV-TRANSFORMED B-CELL LINES
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批准号:2578794
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J M MASSERANO
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依托单位:
THE EFFECTS OF COCAINE ON DOPAMINE UPTAKE IN THE RAT BRAIN
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批准号:5203769
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J M MASSERANO
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依托单位:
THE EFFECTS OF COCAINE ON DOPAMINE UPTAKE IN THE RAT BRAIN
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批准号:3845376
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J M MASSERANO
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依托单位:
THE EFFECTS OF COCAINE ON DOPAMINE UPTAKE IN THE RAT BRAIN
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批准号:3759484
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J M MASSERANO
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依托单位:
REGULATION OF SECOND MESSENGER SYSTEMS IN EBV-TRANSFORMED B-CELL LINES
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批准号:3759520
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J M MASSERANO
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依托单位:
THE EFFECTS OF COCAINE ON TYROSINE HYDROXYLASE ACTIVITY IN THE RAT BRAIN
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批准号:3781477
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J M MASSERANO
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依托单位:
THE EFFECTS OF COCAINE ON TYROSINE HYDROXYLASE ACTIVITY IN THE RAT BRAIN
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批准号:3845377
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J M MASSERANO
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依托单位:
REGULATION OF SECOND MESSENGER SYSTEMS IN EBV-TRANSFORMED B-CELL LINES
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批准号:5203798
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J M MASSERANO
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依托单位:
THE EFFECTS OF COCAINE ON TYROSINE HYDROXYLASE ACTIVITY IN THE RAT BRAIN
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批准号:2578770
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J M MASSERANO
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依托单位:
国内基金
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木薯CC类谷氧还蛋白MeGRXC3修饰Catalase1蛋白调控过氧化氢酶活性的分子机制
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批准号:32360458
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项目类别:地区科学基金项目
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批准号:
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负责人:李斯明
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