MICA: Centre for the Improvement of Population Health through E-health Research (CIPHER)

通过电子保健研究改善人口健康中心的目标是开展改善国民健康的研究。它将通过开发新的方法来匿名，链接和分析医疗保健和类似数据，以回答广泛的重要研究问题。我们将经常与已经建立大型队列研究的研究人员合作，帮助他们使他们的队列更强大，更持久，操作更便宜。电子健康研究是一个新的领域，因此CIPHER将专注于培训研究人员如何使用这些数据和方法。CIPHER有四个核心研究计划：第一个重点是开发强大的新方法，使健康和其他信息能够匿名和分析。例如，开发研究人员访问数据的方法，使其无法识别所涉及的个人，从而确保隐私得到保护。CIPHER的其他三个研究方案侧重于（1）伤害和建筑环境对人们生活的影响;（2）心理健康和物质使用;以及（3）感染。CIPHER研究人员将进行一系列研究，以更好地了解疾病和损伤的原因，这些疾病对个人和人群的后果，以及旨在改善健康的治疗和政策的评估。由于长期研究非常昂贵，目前对许多疾病和治疗的长期个人和社会影响的了解非常有限。CIPHER的工作将使使用匿名数据的结果的长期随访成为可能，有效地回答这些问题，但成本要低得多。在其研究计划中，CIPHER将解决许多科学问题，包括：老年人预防跌倒的措施有多有效？给疗养院的人补充维生素D对减少髋部骨折有什么影响？链接数据可以用来帮助消防和救援服务防止更多的家庭火灾吗？使家庭温暖的干预措施是否减少了冬季的死亡人数？年轻人使用药物对心理健康问题有多大影响？监狱中的阿片类药物替代疗法是否会降低监狱释放后的死亡风险？关联的常规数据是否可以用于确定干预自我伤害或自杀死亡者伤害途径的机会？如何更好地利用信息来减少抗生素耐药性感染？我们肠道中携带的不同微生物是否与严重健康状况的发展有关？CIPHER将与NHS合作，开发更好的方法来衡量患者的经历和治疗结果。CIPHER还将开发方法，将匿名治疗数据与重要的社会成果联系起来，例如继续工作，继续接受教育或能够在家中独立生活。这些信息将有助于NHS设计其服务，以满足更广泛的患者需求。CIPHER认为，与患者、患者团体和广大公众就其研究进行有效沟通是很重要的。因此，我们工作的一个重要部分将是建立帮助这种沟通的方法。我们将有公众代表参与我们的研究，他们将帮助指导我们，并帮助我们与更广泛的群体进行有效的沟通。CIPHER将是英国正在建立的少数类似中心之一，我们将共同努力培训这些新方法的研究人员，并确保大学为他们提供合适的工作。CIPHER的目标是成为一个国际公认的专业知识中心，在使用电子健康和相关记录的研究，并沿着其他网络成员，定位英国作为世界领先的领域，提高人口的健康，增加英国的研究收入，并改善经济。

The aim of the Centre for Improving Population Health through E-Health Research (CIPHER) is to carry out research that will improve the health of the nation. It will do this by developing new methods to anonymise, link and analyse healthcare and similar data, to answer a wide range of important research questions. We will often work with researchers who have established large cohort studies, helping them make their cohorts more powerful, longer lasting, and cheaper to operate. E-health research is a new field and so CIPHER will be focussing on training researchers in how to use these data and methods. CIPHER has four core research programmes: The first focuses on developing robust new methods to allow health and other information to be anonymised and analysed. For example, developing ways in which researchers accessing data cannot possibly identify the individuals involved, thereby ensuring that privacy is protected. CIPHER's other three research programmes focus on the impact on people's lives of (1) injury and the built environment; (2) mental health and substance use; and (3) infection. CIPHER researchers will undertake a range of studies to provide better insight into the causes of disease and injury, the consequences of these conditions on individuals and the population, and evaluations of treatments and policies which are designed to improve health. Knowledge of the longer term individual and societal impact of many conditions and treatments is currently very limited, as long term studies are very expensive. CIPHER's work will enable the long term follow up of outcomes using anonymised data, answering these questions effectively but at far less cost. Within its research programmes CIPHER will address many scientific questions, including: How effective are fall-prevention initiatives for older people? What is the impact of giving Vitamin D supplements to people in care homes in reducing hip fractures? Can linked data be used to help Fire and Rescue services prevent more home fires? Have interventions to make homes warmer reduced the number of deaths in winter? How much does substance use in young adults contribute to mental health problems? Does opiate substitution therapy in prison reduce the risk of death following prison release? Can linked routine data be used to identify opportunities to intervene in pathways to harm for people who self-harm or die by suicide? How can information be better used to reduce antibiotic resistant infections? Are the different micro-organisms we carry in our bowels involved in the development of serious health conditions?CIPHER will work with the NHS to develop better ways to measure patients' experiences and treatment outcomes. CIPHER will also develop methods to enable linkage of anonymised treatment data to important social outcomes such as staying in work, continuing in education, or being able to live independently at home. Such information will help the NHS design its services to meet a broader range of patients' needs. CIPHER's believes it is important to communicate effectively with patients, patient groups and the public at large about its research. A significant part of our work therefore will be setting up ways to aid this communication. We will have public representatives involved in our research throughout and they will help guide us and help us communicate effectively with wider groups. CIPHER will be one of a small number of similar Centres that is being set up in the UK and we will be working together to train researchers in these new methods and making sure universities have suitable jobs for them. CIPHER aims to be an internationally recognised centre of expertise in the use of electronic health and associated records for research and, along with other network members, position the UK as the world leader in the field, improving the population's health, increasing UK research income, and improving the economy.