CHRONIC COCAINE EXPOSURE DURING GESTATION

SPID编号：2 这个项目的目标是调查，在一个非人灵长类动物， 模型，产前可卡因暴露的影响，以了解 更好的风险与可卡因使用在怀孕期间。 临床 报告指出，越来越多的孕妇进行检查， 在分娩期间入院时可卡因呈阳性， 这些妇女和她们的新生儿患上一些疾病的风险增加， 异常 可卡因对妊娠结局的直接影响是 然而，在人类中很难确定，因为一些 混杂因素。 因此，可卡因对母体、胎儿和 对新生儿的行为和发育知之甚少。 这个项目 在恒河猴身上研究服用可卡因的后果 为了表征对妊娠雌性的影响， 发育中的胎儿和由此产生的后代在一个受控的 实验室环境中可卡因的直接贡献， 测定通过长期植入的渗透压输注皮质醇， 微量泵，母体血清和羊水中的药物水平， 监测。 在对照组猴子中，用盐水代替可卡因 溶液 60次怀孕产生了52个后代。 在过去 一年后，受试者接受了认知任务的测试， 以评估学习和记忆的困难。 呼吸 受试者的能力也进行了评估，沿着的发病， 青春期和大脑功能的初步研究使用磁 共振成像 将在研究期间对猴子进行研究和评估。 未来12个月，以完成测试，并将测试， 他们对可卡因的敏感性

SPID#: 2 The objectives of this project are to investigate, in a nonhuman primate model, the effects of prenatal cocaine exposure in order to understand better the risks associated with cocaine use during pregnancy. Clinical reports have indicated that an increasing number of pregnant women test positive for cocaine when admitted to the hospital during labor, and that these women and their newborns are at increased risk for a number of abnormalities. The direct effects of cocaine on pregnancy outcome are difficult to ascertain in humans, however, because of a number of confounding factors. Therefore, cocaine's effects on maternal, fetal and neonatal behavior and development are poorly understood. This project is studying in rhesus monkeys the consequences of cocaine administration during gestation in order to characterize effects on the pregnant female, the developing fetus and the resulting offspring in a controlled laboratory environment where the direct contribution of cocaine can be determined. Cocaine was infused via chronically-implanted osmotic minipumps, and drug levels in maternal serum and amniotic fluid were monitored. In control monkeys, saline was substituted for cocaine solution. Sixty pregnancies produced 52 offspring. During the past year, the subjects were tested on cognitive tasks of increasing difficulty in order to assess learning and memory. The respiratory capabilities of the subjects were also assessed, along with the onset of puberty and preliminary studies of brain functioning using magnetic resonance imaging. The monkeys will be studied and assessed during the next 12 months in order to complete testing, and will also be tested for their sensitivity to cocaine when it is self-administered.