ALDOSE REDUCTASE GENE EXPRESSION IN DIABETIC COMPLICATIONS

本申请的总体目的是表征机制 调节细胞中的醛糖还原酶（AR2，EC1.1.1.21）基因表达 从糖尿病并发症的组织中，并确定 AR2的异常组成性过表达的基础是由一个细胞系， 人视网膜色素上皮（RPE）细胞。 这样做的理由 这一提议基于AR2在人类基因组起源中的假定作用。 糖尿病的慢性并发症，以及越来越多的证据表明AR2 参与生理性神经调节并受其调节。

The overall aim of this application is to characterize the mechanism(s) regulating aldose reductase (AR2,EC1.1.1.21) gene expression in cells from tissues involved in the complications of diabetes, and to determine the basis for abnormal constitutive over-expression of AR2 by a line of human retinal pigment epithelial (RPE) cells. The rationale for this proposal rests on the postulated role of AR2 in the genesis of the chronic complications of diabetes, and the growing evidence that AR2 participates in, and is modulated by, physiological osmoregulation.