ACUTE INTERACTION OF THEOPHYLLINE AND SDZ WAG 994

这项研究是一项双盲、随机、安慰剂对照的临床试验。 试验采用2X2析因设计。我们的目标是评估疗效 抗氧化剂维生素E和C对脂质过氧化的影响。这项研究是 在约翰·霍普金斯大学的门诊综合研究中心进行 巴尔的摩西部的一家医院和健康促进诊所。研究群体 将由180名20岁或以上的健康成年人组成。 参与者参加筛查访问、随机访问和两次 后续补充剂。参与者被随机分成四组 干预组：(1)单独补充维生素E，400IU/d；(2) 单独补充维生素C，每天500毫克，(3)联合维生素E(400 Iu/d)和维生素C(500 mg/d)补充剂，以及(4)安慰剂 治疗。结果指标(F2-异前列腺素和丙二醛)和 中间终点(总氧自由基吸收能力、脂质 尿液和血液中维生素C和维生素E的含量 样品将在实验室完成。

The study is a double-masked, randomized, placebo-controlled clinical trial with a 2X2 factorial design. The goal is to assess the efficacy of antioxidant vitamins E and C on lipid peroxidation. The study is conducted at the Outpatient General Research Center in the Johns Hopkins Hospital and the Pro-Health Clinic in West Baltimore. Study population will consist of 180 healthy adults, aged 20 years or older. Participants attend a screening visit, a randomization visit and two follow-up supplements. Participants are randomized into one of four intervention groups: (1) vitamin E supplementation alone, 400 IU/d, (2) vitamin C supplementation alone, 500 mg/d, (3) combined vitamin E (400 IU/d) and vitamin C (500 mg/d) supplementation, and (4) placebo treatment. Outcome measures (F2-isoprostane and malondialdehyde) and intermediate endpoints (total oxygen-radical absorbance capacity, lipid profiles, and serum levels of vitamin C and E) from urine and blood samples will be done in laboratories.