Developing new therapeutic targets and identifying biomarkers for gestational diabetes and ovarian cancer using extracellular vesicles

妊娠糖尿病（GDM）是澳大利亚增长最快的糖尿病类型。卵巢癌（OVCA）是最致命的妇科癌症，有效的早期诊断对于提高患者生存率至关重要。我希望确定与循环细胞外囊泡（即从所有活细胞释放的纳米囊泡）相关的新机制，并破译它们在调节母体胰岛素敏感性中的作用，以及它们与OVCA进展的关联。

Gestational diabetes mellitus (GDM) is the fastest growing type of diabetes in Australia. Ovarian cancer (OVCA) is the most lethal gynaecological cancer, and an effective early diagnosis is critical with potential to improve patient survival. I expect to identify novel mechanisms associated with circulating extracellular vesicles (i.e. nanovesicles released from all living cells), and decipher their role in regulating maternal insulin sensitivity, and their association with OVCA progression.