UKDP: Integrated DEmentiA research environment (IDEA)

英国痴呆症平台（UKDP）是一种全新的痴呆症研究方法。它汇集了来自22个队列的约200万研究参与者的数据，试图发现痴呆症的原因，并找到减缓痴呆症的方法。该平台已获得1200万英镑的融资。在这项提案中，我们希望改善英国痴呆症研究的基础设施，以便最大限度地利用UKDP提供的机会。我们希望通过购买重要的设备来改善基础设施，这些设备将使英国处于全球痴呆症研究的前沿，并通过建立科学家网络来共同努力，充分利用这些设备。提案的三个主题是成像、信息学和干细胞。在成像方面，我们希望在英国建立一个PET/MR扫描设备网络，这样就可以研究大脑内部导致痴呆的分子过程。在信息学方面，我们希望汇集尽可能多的不同类型的数据，并使科学家尽可能容易地使用它们。在干细胞方面，我们希望从患有和不患有痴呆症的成年人身上提取细胞，以发现随着痴呆症过程的开始和发展，细胞是如何变化的。我们相信这些提案将提高标准，降低成本，并提供创新和协调的研究，使英国成为研究痴呆症的国际独特之地。

The UK Dementias Platform (UKDP) is a radically new approach to dementias research. It brings together data fromaround 2,000,000 study participants from 22 cohorts to try and discover the causes of dementia and to find out ways ofslowing it down. The platform has been funded to the level of £12M.In this proposal we want to improve UK infrastructure for dementia research so that the most can be made of theopportunity provided by UKDP. We wan to improve the infrastructure by buying important pieces of equipment that will putthe UK at the forefront of dementia research worldwide and by establishing networks of scientists who will work together tomake best use of the equipment.The three themes of the proposal are imaging, informatics and stem cells.For imaging we want to establish a network of PET/MR scanning facilities across the UK so that the molecular processesgoing on inside the brain that cause dementia can be studied.For informatics we want to be bring together bas many different types of data as possible and make it easy as possible forscientists to use themFor stem cells we want to take cells form adults with and without dementia to find out how cells change as the dementiasprocess begins and progresses.We believe these proposals will raise standards, reduce costs, and deliver innovative and coordinated research, makingthe UK an internationally unique place to study dementia.