Newton001 Leishmaniasis in the Brazilian Amazon: the role of accessory microbiota in disease progression, pathobiology and immunity.

利什曼原虫在巴西，感染是一个严重的公共卫生负担，每年有3.5万例疑似病例。毁容、有时致命的皮肤和粘液皮肤型利什曼病在巴西亚马逊地区最为常见。不同的临床严重程度和耐药谱在患者之间被广泛报道。因此，迫切需要确定哪些因素可能会导致不同的患者结果。利什曼原虫的种类和基因与宿主的免疫反应一样，在定义疾病严重程度方面起着作用。较少考虑的是继发性细菌感染和共生皮肤微生物区系在调节病理和免疫中所起的作用。在这个多学科项目中，我们建议使用最先进的技术来监测利什曼原虫病变相关微生物多样性和宿主免疫反应，以揭示巴西亚马逊地区皮肤利什曼原虫病严重程度和进展的潜在因素。

Leishmania spp. infection represents a serious public health burden in Brazil, with 35,000 suspected cases annually. Disfiguring and occasionally fatal cutaneous and muco-cutaneous forms of Leishmaniasis are most common in the Amazon region of Brazil. Differential clinical severity and drug-resistance profiles are widely reported between patients. There is thus an urgent need to identify what factors might be responsible for different patient outcomes. Leishmania species and genotype have a role in defining disease severity, as does the host immune response. Less commonly considered is the role that secondary bacterial infections and commensal skin microbiota have in modulating pathology and immunity. In this multidisciplinary project we propose to use state-of-the-art techniques to monitor Leishmania lesion-associated microbial diversity and host immune response to reveal the factors that underlie cutaneous Leishmaniasis severity and progression in Amazonian Brazil.