Developing novel therapeutic approaches to treat chronic kidney disease

慢性肾脏疾病(CKD)进展到终末期的特点是炎症和纤维化。目前尚无有效阻止CKD进展的治疗方法。我们正在使用保护性免疫细胞治疗CKD，并发明了一种基因工程免疫细胞，它使用破坏性炎症信号将它们转换为保护性细胞，在发生炎症和纤维化的地方逆转炎症和纤维化，以防止CKD和其他疾病的发展，如心脏、肺和肝脏的疾病。

Progression of chronic kidney disease (CKD) to endstage is characterised by inflammation and fibrosis. No current treatment effectively halts CKD progression. We are using protective immune cells to treat CKD and have invented a genetically-engineered immune cell which uses damaging inflammatory signals to switch them into protective cells which reverse inflammation and fibrosis where they occur, to prevent progression of CKD and other diseases, such as those of heart, lung and liver.