SOCIAL REGULATION OF REPRODUCTIVE ENDOCRINOLOGY

雌性普通绒猴的繁殖能力完全是 受社会地位的制约。下级雌性没有卵巢 活动和低水平的垂体促性腺激素，但 下丘脑促性腺激素释放激素(GnRH)的输出不 与骑自行车占主导地位的雌性相比，这是不同的。目前的研究 将系统地检查几个神经内分泌参数 沿着下丘脑-垂体-性腺轴的穴位 描述社会状态之间的任何细微差异。结果 将确定心理社会因素可以影响的机制 通过微小的变化实现生殖的完整性，而不是戏剧性的 全球变化，神经内分泌环境。 在所有研究中，促性腺激素释放激素和黄体生成素的参数将是 测量并比较优势、2级和3级女性之间的差异。 雌性将接受柄-正中隆起的推拉灌流 同时每隔10分钟采一次血，最多10小时。 实验1将寻找改变的下丘脑GnRH昼夜模式 和垂体促黄体生成素的释放。实验2将表征促性腺激素释放激素和促黄体生成素 有能力或无能力产生排卵的反应 黄体生成素对雌二醇的反应激增。实验3将检验 不同的垂体刺激和对标准化的反应性 GnRH挑战；GnRH受体浓度将被量化。

Female common marmoset monkey reproductive capacity is completely regulated by social status. Subordinate females show no ovarian activity and have low levels of pituitary gonadotropins, yet hypothalamic gonadotropin-releasing hormone (GnRH) output is not different when compared to cycling dominant females. The present study will systematically examine neuroendocrine parameters at several points along the hypothalamic-pituitary-gonadal axis in order to characterize any subtle differences between social states. Results will identify mechanisms by which psychosocial factors can influence reproductive integrity through small variations, rather than dramatic global changes, in the neuroendocrine environment. In all studies GnRH and luteinizing hormone (LH) parameters will be measured and compared between dominant, rank 2 and rank 3 females. Females will undergo push-pull perfusion of the stalk-median eminence with concomitant blood sampling at 10 min intervals for up to 10 hr. Experiment 1 will look for altered diurnal patterns hypothalamic GnRH and pituitary LH release. Experiment 2 will characterize GnRH and LH responses underlying the ability or inability to generate an ovulatory LH surge in response to estradiol. Experiment 3 will examine differential pituitary stimulation and responsiveness to standardized GnRH challenges; GnRH receptor concentrations will be quantified.