BEHAVIORAL AND NEURAL ANALYSIS OF FEEDING IN APLYSIA

预设方案中描述的实验旨在 确定开始喂食的机制使用简单的 系统，软体动物Aplysia calfornica。既有前期吸收(例如，缓解 肠拉伸)和吸收后(例如血糖)因素将是 被调查为启动刺激。一旦启动刺激是 了解的电生理学技术将用于 研究与脑出血相关的信号的神经元作用部位。 启动刺激，使用半完整和活体准备。在……里面 此外，神经束追踪和神经染色的解剖学技术 将被用来确定这些病毒的可能传播路线 刺激物。其目的是从以下方面推导出一般原则 理解在这种情况下开始摄食的生理学 简单的系统可以应用于脊椎动物的摄食系统 行为，无论是在健康状态下还是疾病状态下。

The experiments described in the preset proposal are designed to determine the mechanism for the initiation of feeding using a simple system, the mollusc Aplysia californica. Both preabsorptive (e.g., relief of gut stretch) and postabsorptive (e.g., blood glucose) factors will be investigated as initiating stimuli. Once the initiating stimuli are understood electrophysiological techniques will be employed to investigate the neuronal sites of action of the signals related to the initiating stimuli, using semi-intact and in vivo preparations. In addition, anatomical techniques of tract tracing and neural staining will be used to determine possible routes of transmission of these stimuli. It is the intention that general principles derived from understanding the physiology of the initiation of feeding in this simple system can be applied to vertebrate systems of feeding behavior, both in healthy and diseased states.