UK-India Centre for Advanced Technology for Minimising the indiscriminate use of

抗生素耐药性正在成为我们这个时代最重要的挑战之一。如果我们要避免体面地进入后抗生素时代，存在许多挑战，包括：开发新的抗生素；新的诊断方法和改进的交付系统。英国-印度最大限度地减少滥用抗生素先进技术中心（UKICAT-MA）将建立用于在护理点检测眼部感染和有针对性地向眼睛感染部位递送抗生素的材料。UKICAT-MA还将促进在其他传染病中使用这些技术。该中心涉及来自谢菲尔德大学的多学科团队（聚合物化学，临床和机械微生物学以及LV Prasad眼科）。大部分工作都是基于这样一种观点，即某些材料通过改变与细菌结合的状态来对细菌做出反应。然后对这些构象变化进行监测，以提供细菌存在的信号，或者为抗生素靶向细菌提供基础，同时减少对周围组织的影响。UKICAT-MA将开发这些智能材料来生产隐形眼镜，这种隐形眼镜可以提供细菌感染的比色指示，也可以为受感染的眼部组织局部输送治疗药物。该中心涉及基础科学活动，旨在了解结合相互作用，这是这些材料的关键方面，材料开发和生产战略的发展，直至临床试验。英国和印度之间的密切合作将促进这一雄心勃勃的计划，每个合作伙伴都将带来重要的专业知识，以有效和快速地将这些技术应用于临床。UKICAT-MA还将寻求与新的合作伙伴合作：工业、临床和科学方面的专业知识，而不是眼睛感染。为了促进这些进一步的研究，我们将在印度和英国举办一系列研讨会。

Resistance to antibiotics is becoming one of the most important challenges of our age. A number of challenges exist if we are to avoid decent into a post-antibiotic age, including development of: new antibiotics; new diagnostics and improved delivery systems. The UK-India Centre for Advanced Technology for Minimising the indiscriminate use of Antibiotics (UKICAT-MA) will establish materials for both detection, at the point-of-care, of ocular infections and the targeted delivery of antibiotics to infected sites in the eye. UKICAT-MA will also promote the use of these technologies in other infective diseases. The Centre involves a multidisciplinary team from the University of Sheffield (Polymer Chemistry, Clinical and Mechanistic Microbiology and LV Prasad Ophthalmology). Much of the work is based around the idea that certain materials respond to bacteria by changing state on binding to bacteria. These conformational changes are then either monitored to provide a signal of the presence of the bacteria or they provide a basis for targeting antibiotics to bacteria whilst reducing effects on surrounding tissues. UKICAT-MA will develop these smart materials to produce contact lenses that give colourimetric indications of bacterial infections and systems for local delivery of therapeutics to infected ocular tissues. The Centre involves basic science activities, which are aimed at understanding the binding interactions that are key aspects of these materials, materials development and development of manufacturing strategies through to clinical trials. Close collaborative working between the UK and India will facilitate this ambitious programme and each partner brings important expertise to progress these technologies efficiently and quickly to the clinic. UKICAT-MA will also look to collaborate with new partners: industrial, clinical and scientific with expertise of infections other than in eyes. To facilitate these further researches we will run a series of workshops in both India and the UK.