ALCOHOL RESEARCH--RISK AND PROTECTION IN ETHNIC GROUPS

加州大学圣地亚哥分校精神病学系 特此代表塔玛拉·L·沃尔申请独立科学家 国家酒精滥用和酒精中毒研究所颁发的奖项(KO2) (NIAAA)。拟议的研究事业奖的总体目标是 将候选人从临床和行政职责中解放出来，以便她 可能会投入几乎全职的时间继续和发展她的研究 评估青少年饮酒的风险和保护因素 不同的民族。亚裔美国人和美洲印第安人 在模式、流行和后果方面差异很大 酗酒。这些差异被认为是由 生物和心理社会因素的综合作用。 该应用程序有两个总体目标：1)完成两个项目 目前由NIAAA资助的重点是了解 亚裔美国人和原住民对酒精反应的遗传影响 美国印第安人；和2)通过评估 生物和心理社会影响的综合作用 饮酒模式和这些民族中使用酒精的问题 横截面数据，最终是纵向数据。取得的成果 这些研究将提供有关 生物和环境方面之间的复杂关系 对酗酒的脆弱性和对酒精中毒的保护。候选人有 对与酒精相关的研究做出了坚定的承诺。为她举办的活动 持续的职业发展将包括：1)密集的新培训 与领先的研究科学家一起研究心理社会的重要性 酒精使用和酒精问题发展模式中的因素， 统计建模技术和纵向研究设计；2) 关于高级结构建模和负责任的行为的课程 研究；以及3)参加院系研讨会和科学研究 开会。

The University of California, San Diego (UCSD), Department of Psychiatry hereby applies on behalf of Tamara L. Wall for an Independent Scientist Award (KO2) from the National Institute on Alcohol Abuse and Alcoholism (NIAAA). The overall aim of the proposed Research Career Award is to free the candidate from clinical and administrative duties so that she may devote nearly full-time to continue and develop further her research evaluating risk and protective factors for alcohol involvement within different ethnic groups. Asian Americans and Native American Indians vary greatly with respect to patterns, prevalences, and consequences of alcohol use. These differences are hypothesized to result from a combination of biological and psychosocial factors. This application has two overall goals: 1) to complete two projects currently funded by NIAAA focused on understanding the effects of genetic influences on response to alcohol in Asian Americans and Native American Indians; and 2) to expand upon these studies by evaluating the combined contributions of biological and psychosocial influences on alcohol drinking patterns and problems within these ethnic groups using cross-sectional, and eventually longitudinal, data. Results obtained from these studies will provide important information regarding the complex relationship between biological and environmental aspects of vulnerability to, and protection from, alcoholism. The candidate has made a strong commitment to alcohol-related research. Activities for her continued career development will include: 1) intensive new training with leading research scientists in the importance of psychosocial factors in developmental models of alcohol use and alcohol problems, statistical modeling techniques, and longitudinal research design; 2) coursework on advanced structural modeling and the responsible conduct of research; and 3) participation in department seminars and scientific meetings.