PREGNANCY, HYPOXIA AND TRANSCRIPTIONAL REGULATION OF NO

描述 （改编自申请人摘要）Margueritte白色博士是助理 医学教授谁已经完成了联合临床和研究 产科母婴医学研究金 心血管和肺研究实验室（CVP） 科罗拉多大学。 她目前是MIRS的接收者 该奖项支持了她在过去两年中在CVP的工作， 1998年3月结束。 她最近完成了一整年的研究生课程 博士学位所需的课程分子生物学专业的候选人 （高等分子生物学，分子遗传学，细胞生物学和分子生物学） 病毒学）。 通过她的奖学金迄今为止，她一直在工作， Lorna摩尔博士在CVP的指导，医学教授，谁是 国内和国际公认的人类和动物研究 高海拔对母体血管调节的影响， 怀孕 这一合作产生了两个第一作者 同行评审的出版物，一份正在编写的手稿，四份 在国家会议上提出的摘要。 此外，白色博士 为其他出版物和摘要撰稿并担任合著者 从这部作品中散发出来（传记素描）。 白色博士的研究 集中在一氧化氮在改变血管反应性中的作用， 在常氧和长期缺氧条件下怀孕。 她是 扩展她的研究，迄今为止在豚鼠离体血管中进行 环，到细胞水平，以研究分子机制， 妊娠和慢性缺氧会影响 内皮型一氧化氮合酶基因。 为此，此外， 到完成分子生物学研究生课程，她建立了一个 与Benamin Perryman博士的合作和指导关系， 医学教授，在细胞系和 结构生物学和跨部门分子生物学计划。 这种合作导致了最近的一个抽象的介绍， 全国会议。 白色博士将根据 洛娜摩尔和本佩里曼博士的直接监督， 实验室有相当多的专业知识，在研究血管生物学 和基因调控机制。 白色博士的项目 汇集了两个国家认可的卓越中心的专业知识， 研究和培训，心血管肺实验室和 分子生物学课程都在毗邻的建筑物内的学校 药 白色博士的建议的优点在于她运用了 最先进的技术在分子生物学探索的问题 生理重要性的母体血管调整怀孕。

DESCRIPTION (Adapted from applicant's abstract) Dr. Margueritte White is an Assistant Professor of Medicine who has completed a joint clinical and research fellow-ship in Maternal Fetal Medicine through the Department of Obstetrics and Gynecology and the Cardiovascular Pulmonary Research Laboratory (CVP) at the University of Colorado. She is presently the recipient of the MIRS award which has supported her work in the CVP for the past 2 years and which ends in March 1998. She has recently completed a full year of graduate level courses required for Ph.D. candidates in the Molecular Biology Program (Advanced Molecular Biology, Molecular Genetics, Cell Biology and Molecular Virology). Through her fellowship to date, she has worked under the mentorship of Dr. Lorna Moore in CVP, Professor of Medicine, who is nationally and internationally recognized for her human and animal studies on the effects of high altitude on maternal vascular adjustments to pregnancy. This collaboration has resulted in two first author peer-reviewed publications, one manuscript in preparation, and four abstracts presented at national meetings. In addition, Dr. White has contributed to and been co-author on additional publications and abstracts emanating from this work (biographical sketch). Dr. White's research has focused on the role of nitric oxide in altering vascular reactivity during pregnancy under normoxic and chronically hypoxic conditions. She is extending her studies, thus far performed in guinea pig isolated vessel rings, to a cellular level in order to investigate molecular mechanisms by which pregnancy and chronic hypoxia influence transcriptional regulation of the endothelial nitric oxide synthase gene. Towards that end, in addition to completing graduate courses in molecular biology, she has established a collaborative and mentoring relationship with Dr. Benamin Perryman, Professor of Medicine with joint appointments in the Department of Cell and Structural Biology and the interdepartmental Molecular Biology Program. This collaboration has resulted in a recent abstract presentation at a national meeting. Dr. White will carry out the proposed studies under the direct supervision of Drs. Lorna Moore and Ben Perryman in whose laboratories there is considerable expertise in studying vascular biology and mechanisms of gene regulation, respectively. Dr. White's project brings together expertise from two nationally recognized centers of excellence in both research and training, the Cardiovascular Pulmonary Lab and the Molecular Biology Program both in adjoining buildings within the School of Medicine. The strength of Dr. White's proposal lies in her application of state of the art techniques in molecular biology to explore questions of physiologic importance regarding maternal vascular adjustments to pregnancy.