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EMF AND BREAST CANCER ON LONG ISLAND

EMF AND BREAST CANCER ON LONG ISLAND
长岛的电磁场与乳腺癌
批准号:
2903353
负责人:
MCRISTINA LESKE
金额:
$48.41万
依托单位国家:
美国
项目类别:
财政年份:
1993
资助国家:
美国
项目状态:
已结题
起止时间:
1993-09-30 至 2001-02-28

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中文摘要
翻译
多年来,长岛的乳腺癌发病率一直在上升。 过去几年。拿骚和萨福克县都是 纽约州,它本身的发病率高于美国全国 平均。长岛乳腺癌研究,一项大型病例对照研究 S在20世纪80年代中期进行的一项研究发现,标准的风险因素只能解释 超额发病率的一小部分。因此,我们提出这样的建议 研究考察了几个已经被 推测与乳腺癌有关。 最近对实验动物的研究表明,电磁 大约60赫兹的辐射(EMF)可能通过以下方式与乳腺癌有关 抑制松果体分泌褪黑素。通过减少 褪黑激素的分泌,它可能会增加雌激素的产生, 已确定的乳腺癌危险因素。此外,最近的几个 小规模研究发现更高水平的环境广布 乳腺癌患者乳房脂肪组织中有机氯化合物的检测 而不是控制。最近的这些报道引起了龙的极大关注 岛屿妇女,鉴于电磁辐射的高使用率和 此前长岛有机氯农药使用量较高。 因此,我们建议进行一项病例对照研究,将乳房 控制女性的癌症病例。这项研究将仅限于这些女性 在同一所房子里居住至少十五年。电动势测量 将在这些住宅内外制造,以及化学物质 将对这些妇女的血清进行分析。家庭粉尘样本 将在随机抽取的女性样本中收集和分析。级别 有机氯农药残留将在血清和粉尘中进行比较 样本。此外,一份详细的调查问卷将发放给 每个参与者,以便获得有关环境的信息 暴露和标准的乳腺癌危险因素。希望这是一次 研究将有助于阐明乳腺癌高发的原因 长岛的发病率。
英文摘要
The incidence of breast cancer on Long Island has been increasing over the past few years. Both Nassau and Suffolk Counties rank among the highest in New York State, which itself has a higher incidence than the U.S. national average.The Long Island Breast Cancer Study, a large case-control study conducted in the mid 1980's found that standard risk factors explain only a fraction of the excess incidence. Therefore, we are proposing this study to examine several environmental factors which have been hypothesized to be associated with breast cancer. Recent work with laboratory animals has suggested that electromagnetic radiation (EMF) of about 60 hz might be associated with breast cancer by inhibiting secretion of melatonin by the pineal gland. By reducing melatonin secretion, it could be increasing estrogen production, a well established risk factor for breast cancer. In addition, several recent small-scale studies found higher levels of environmentally widespread organochlorine compounds in breast adipose tissue of breast cancer cases than controls. These recent reports have created much concern among Long Island women, given the high usage of electromagnetic radiation and the previously high usage of organochlorine pesticides on Long Island. We are therefore proposing to do a case-control study comparing breast cancer cases to control women. The study will be limited to those women residing in the same house for at least fifteen years. EMF measurements will be made both inside and outside these residences, and chemical analyses will be done on serum from these women. Household dust samples will be collected and analyzed on a random sample of women. Levels of organochlorine pesticide residues will be compared between serum and dust samples. In addition, a detailed questionnaire will be administered to each participant in order to gain information regarding environmental exposures and standard breast cancer risk factors. It is hoped that this study will help to clarify the reasons for the high breast cancer incidence on Long Island.
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