PERIOPERATIVE WOUND LEAKS AFTER TRABECULECTOMY IN FFSS

本申请提出了进一步的分析 氟尿嘧啶滤过手术研究（FFSS）中收集的数据。FFSS 是一项NEI申办的多中心随机临床试验， 有和没有术后，结膜下小梁切除术的结果 注射5-氟尿嘧啶（5-FU），在病情不佳的患者中， 特别是既往接受过白内障摘除术的患者或 之前滤过手术失败。本次调查的目的是：（1） 评估围手术期伤口渗漏的风险（伤口渗漏 在手术后的前两周内）的成功率 小梁切除术; 2）确定术前，术中， 发生围手术期伤口渗漏的术前风险因素;以及3） 记录围手术期伤口渗漏患者的其他不良结局， 如眼内炎、低眼压和迟发性伤口发展 漏水 FFSS仔细检查了所有结膜伤口与日常赛德尔 在前两个治疗组中对所有患者进行检测 术后数周。因此，这项研究提供了一个独特的数据库，以检查 手术结果问题和围手术期滤过泡渗漏的风险因素。 由于抗代谢药的使用在青光眼手术中变得越来越普遍， 在以前没有接受过眼科手术的患者中， 围手术期伤口渗漏的原因应有助于指导治疗， 需要小梁切除术的青光眼患者。

DESCRIPTION: (Applicant's Abstract) this application proposes further analyses of data collected in the Fluorouracil Filtering Surgery Study (FFSS). The FFSS was an NEI-sponsored, multicenter, randomized clinical trial to compare the results of trabeculectomy with and without postoperative, subconjunctival injections of 5-fluorouracil (5-FU), in patients with poor prognoses, specifically patients with previous cataract extraction or phakic patients with previously failed filtering surgery. The goals of this investigation are 1) to evaluate the risk of perioperative wound leaks (wound leaks which develop within the first two postoperative weeks after surgery) on the success rate of trabeculectomy; 2) to determine the preoperative, intraoperative, and preoperative risk factors for developing perioperative wound leaks; and 3) to document other adverse outcomes of patients with perioperative wound leaks, such as endophthalmitis, hypotony, and the development of late-onset wound leaks. The FFSS carefully scrutinized all conjunctival wounds with daily Seidel testing of all patients in both treatment groups during the first two postoperative weeks. This study thus provides a unique database to examine the question of surgical outcome and the risk factors for perioperative bleb leaks. Since antimetabolite use is becoming more common in glaucoma surgery, even among patients who have had no previous ocular surgery, insight into the risks and causes of perioperative wound leaks should be useful to guide therapy in glaucoma patients who require trabeculectomy.