MAGNETIC FIELDS, MEDICATIONS, AND BREAST CANCER

本病例对照研究的主要目的是确定在诊断前10年（或对照参考日期）内定期服用选定类型处方药（β受体阻滞剂、钙通道阻滞剂、精神药物）的女性中，在住宅环境中暴露于60 Hz磁场和/或夜间光照（LAN）是否会增加乳腺癌风险。这项拟议的研究是由研究小组刚刚完成的一项研究（褪黑激素研究）中的具体发现提出的，该研究证明了磁场暴露对这些药物使用者的女性夜间褪黑激素水平的影响。研究小组刚刚完成的一项与住宅磁场和LAN有关的乳腺癌大型病例对照研究（母研究）没有评估此类暴露对使用这些药物的女性亚组中乳腺癌风险的潜在影响。本研究的目的是获得药物治疗史数据的妇女谁参加了父母的病例对照研究，使更多的生物学指导的分析，可以进行建议的结果从褪黑激素的研究。将邀请参与母研究的仍然存活且可找到的女性参与（预计约为1，471例女性）。数据收集将包括电话访谈，旨在收集相关药物（β受体阻滞剂、钙通道阻滞剂和精神药物）的使用数据。为了掩盖额外数据收集的主要目的，还将询问有关维生素补充剂和运动习惯的问题，包括使用特定类型的运动器材。将向每例受试者发送一封介绍信，描述研究并要求其参与。信件寄出后大约三到五天，一位受过训练的面试官将打电话给受试者，邀请她参加。如果受试者同意，将安排电话访谈的日期和时间，并安排提前资料包，并在安排的访谈前向受试者发送提前资料包。高级数据包将包含一封信，描述访谈中要解决的主题领域，以及帮助重建和回忆过去十年中药物使用的材料。将进行条件logistic回归分析，以评价乳腺癌风险与磁场或光照暴露之间的关系是否在有使用和未使用任何关注药物史的受试者中存在差异。

The primary purpose of this case-control study is to determine whether exposure to 60-Hz magnetic fields in a residential setting and/or light- at-night (LAN) increases the risk of breast cancer in women who have regularly taken selected types of prescription medications (beta blockers, calcium channel blockers, psychotropics) in the ten years prior to diagnosis (or reference date for controls). The proposed study is prompted by specific findings in a study just completed by the research team (the melatonin study) that demonstrate effects of magnetic field exposure on nocturnal melatonin levels among women who are users of these classes of medication. A large case-control study of breast cancer in relation to residential magnetic fields and LAN, also just completed by the research team (parent study), did not evaluate the potential effects of such exposures on breast cancer risk among subgroups of women defined by the use of these medications. The present study is designed to obtain medication history data for women who participated in the parent case-control study so that more biologically directed analyses can be undertaken as suggested by the findings from the melatonin study. Women who participated in the parent study who are still alive and can be located will be invited to participate (anticipated to be approximately 1,471 women). Data collection will consist of a telephone interview designed to collect data on the use of the medications of interest (beta blockers, calcium channel blockers, and psychotropics). In an effort to disguise the primary purpose of the additional data collection, questions will also be asked about vitamin supplements and exercise habits, including the use of specific types of exercise equipment. Each subject will be sent an introductory letter describing the study and asking for her participation. Approximately three to five days after the letter has been mailed, a trained interviewer will call the subject and invite her to participate. If the subject agrees, a date and time for a telephone interview will be scheduled, and an advance packet of material will be scheduled, and an advance packet of material will be sent to the subject prior to the scheduled interview. The advanced packet will contain a letter describing the topic areas to be addressed in the interview, and materials to aid in the reconstruction and recall of medication use during the previous ten years. Conditional logistic regression analyses will be conducted to evaluate whether any relationship between the risk of breast cancer and exposure to magnetic fields or light-at-light varies among subjects with a history of using and not using any of the medications of interest.