NOVEL PHOTOCHEMICALLY-ACTIVATED TISSUE GLUE

这个项目涉及一种新的系统，可以提供无缝合的组织修复。光化学激活的1，8-萘酰亚胺将被引入到壳聚糖基聚合物中，从而将新型专利1，8-萘酰亚胺化合物的组织粘合能力与壳聚糖的伤口愈合和止血性能结合在一起。这种萘酰亚胺“胶”将被用来粘着邻近的组织或将“贴片”贴在受伤的动脉部位。潜在的血管应用范围非常广泛，从简单的动脉切开闭合到控制大出血。一种可以促进止血和伤口修复的技术将改善患者护理，降低发病率和死亡率，并有可能降低医疗成本。这种福利将在医疗行业得到很好的接受。这种产品的市场范围从诊所到急诊室再到手术室。在本次第一阶段应用中提出的可行性研究中，我们将设计和制造一种载萘酰亚胺的壳聚糖凝胶，其中双功能萘酰亚胺通过暗反应附着到壳聚糖凝胶上，并通过光反应附着到邻近的反应部位。将开发两种萘酰亚胺化合物，以促进壳聚糖凝胶本身以及凝胶与被粘连组织之间的结合。还将进行组织结合能力的初步测试。拟议的商业应用：这项研究将最终导致一种组织粘合化合物的生产、营销和销售，该化合物将可供诊所和医院购买，并供医疗专业人员使用。该产品将包括载萘酰亚胺的壳聚糖凝胶和完整的使用和照射说明。此类产品的市场将包括目前使用标准修复技术进行动脉修复的所有诊所和医院。

This project involves a novel system that would provide sutureless tissue repair. Photochemically-activated 1,8-naphthalimides would be incorporated into a chitosan-based polymer, thus combining the tissue-bonding capabilities of novel, patented 1,8-naphthalimide compounds with the wound-healing and hemostatic properties of chitosan. This naphthalimide "glue" will be used to adhere adjacent tissues or to apply a "patch" to an injured arterial site. The range of potential vascular applications is very broad, from simple arteriotomy closure to control of massive hemorrhage. A technique which could facilitate hemostasis and wound repair would improve patient care, reduce morbidity and mortality, and potentially reduce health care costs. Such benefits would be well received in the medical industry. The market for such a product spans from the clinic to the emergency room to the surgical suite. In the feasibility studies proposed in this Phase I application, we will design and manufacture a naphthalimide-loaded chitosan gel where the bifunctional naphthalimide is adhered to the chitosan gel via dark reaction and to adjacent reactive sites via light reaction. Two species of naphthalimide compounds will be developed to facilitate bonding within the chitosan gel itself, and between the gel and the tissues to be adhered. Preliminary testing of tissue-bonding capabilities will be also be conducted. PROPOSED COMMERCIAL APPLICATIONS: This research will culminate in the production, marketing, and sales of a tissue-bonding compound that would be available for purchase by clinics and hospitals and use by medical professionals. The product would include the naphthalimide-loaded chitosan gel and complete instructions for application and irradiation. The market for such a product will include all clinics and hospitals who are currently performing arterial repair using standard repair techniques.