DEVICE FOR SIMULTANEOUS ABR/OAE ACQUISITION

在第一阶段，研究并论证了ABR-TEOAE同步采集系统的可行性。对12名成年人的数据进行了离线收集和处理。进行了三个实验。在实验L中，论证了利用线性、非线性、交变和非交变刺激同时采集ABR和TEOAE的可行性。在实验2中，实现了一种替代的刺激伪迹抑制方法--缩放模板减法(STS)，并成功地对其进行了测试。实验表明，线性刺激结合STS方法至少有三个优点：a)提供了更准确的伪阈值，b)减少了伪影污染，c)提供了更有效的数据采集。实验3测试了一种跨通道噪声抵消技术，并证明了同时使用脑电和声输入的噪声水平可以提高OAE和ABR的信噪比。在第二阶段，这些技术将被实时实施，并扩大到包括纯音刺激。还将开发一种具有更宽的频率和强度范围以及刺激伪影消除前置放大器的新探头。临床试验将在第二年进行，以在一系列操作条件下测试该系统，包括术中监测和婴儿听力筛查。拟议的商业应用：拟议的TEOAE/ABR系统将使临床医生能够同时使用TEOAE和ABR来评估听力状况。先进的刺激伪迹消除方法将提高伪阈值的确定和测试效率，减少刺激伪迹污染。拟议中的设备将立即在听力测试的所有领域得到商业应用。

During Phase I, the feasibility of a simultaneous ABR-TEOAE acquisition system was studied and demonstrated. Data from 12 adults were collected and processed off-line. Three experiments were conducted. In experiment l, the feasibility of simultaneous ABR and TEOAE acquisition using linear, non-linear, alternating and non-alternating stimuli was demonstrated. In experiment 2, an alternative stimulus artifact reduction method, Scaled Template Subtraction (STS), was implemented and tested successfully. The experiment showed that linear stimulation combined with the STS method has at least three advantages over the current Derived Non-Linear Method used to acquire TEOAEs: it a) provides more accurate pseudo-thresholds, b) reduces artifact contamination, and c) provides for more efficient data acquisition. Experiment 3 tested a cross-modality noise cancellation technique and demonstrated that both OAE and ABR signal- to-noise ratios can be improved by using noise levels from EEG and acoustic inputs simultaneously. During Phase II, these techniques will be implemented in real-time and expanded to include pure tone stimulation. A new probe with a broader frequency and intensity range and stimulus artifact canceling preamplifier will also be developed. Clinical trials will be conducted in Year 2 to test the system under a range of operating conditions, including intraoperative monitoring and infant hearing screening. PROPOSED COMMERCIAL APPLICATION: The proposed TEOAE /ABR system will enable clinicians to evaluate hearing status using both TEOAEs and ABRs simultaneously. Advanced stimulus artifact cancellation methods will improve pseudo-threshold determination and testing efficiency and reduce stimulus artifact contamination. The proposed device will find immediate commercial application in all areas of hearing testing.