Determinants and Mechanisms Involved in Alcohol Consumption and its Health Consequences

在目前提议的研究中，我将使用来自英国生物库、AirWave健康监测研究和出版的全基因组关联研究以及动物模型的遗传、环境和代谢物数据，以突出酒精消费和相关疾病的决定因素、机制和途径。我将使用英国生物库的数据来研究酒精消费的风险因素和决定因素，以及酒精消费引起的疾病。通过使用AirWave研究中的酒精消费数据和代谢物，我将识别与酒精相关代谢物相关的基因。然后，我将在英国生物库研究中测试酒精代谢物基因，以强调与酒精消费在肝脏中积累脂肪有关的途径。我还将测试动物模型，以确定基因与饮酒之间的关联背后的潜在生物学。

In the current proposed research, I will be using genetic, environmental and metabolite data from the UK Biobank, the Airwave health monitoring study and published genome-wide association studies as well as animal models in order to highlight determinants, mechanisms and pathways involved in alcohol consumption and related diseases. I will use UK Biobank data to study risk factors and determinants of alcohol consumption as well as diseases caused by alcohol consumption. By using alcohol consumption data and metabolites in the Airwave study, I will identify genes that are linked to alcohol-related metabolites. I will then test alcohol-metabolite genes in the UK Biobank study to highlight pathways that are linked to fat accumulation in liver via alcohol consumption. I will additionally test animal models to identify the underlying biology behind the association of genes and alcohol consumption.