Force in Migration: The mechanism of Nuclear Force Coupling driven invasive cell migration

细胞迁移是人体许多过程的基础，其失调可能导致各种各样的病理，包括癌细胞侵袭和过早老化细胞中受损的细胞运动。组织中的细胞需要感知其环境的物理性质-例如刚度或灵活性-并且它们可以相应地调整其行为和形状。该提案旨在研究细胞如何有效地将外部物理信号直接传递到细胞核，以实现细胞迁移和基因转录的变化。这将有助于理解施加在细胞核上的力如何驱动癌细胞侵入周围组织。

Cell migration is fundamental for many processes in the human body and its deregulation can lead to a vast variety of pathologies including cancer cell invasion and impaired cell locomotion in prematurely ageing cells. Cells in tissues need to sense the physical qualities -for example the stiffness or flexibility- of their environment and they can adapt their behaviour and shape accordingly. This proposal aims to investigate just how cells effectively transmit signals caused by physical cues on their outside directly to their nucleus to enable cell migration and changes in gene transcription. This will help to understand how forces applied to the nucleus can drive cancer cell invasion into surrounding tissues.