CORE--METHODOLOGY AND DATA MANAGEMENT

方法和数据管理核心至关重要 为该MAMDC及其EEHSR组件在 很特别。集中提供数据库和 学习表单构建；数据录入、监控和检索； 用于检验假设和控制的各种分析技术 潜在的混杂因素对所有调查人员来说都是必不可少的资源。这个 CORE曾协助教育工作者、流行病学家和卫生服务机构 来自几个部门的研究人员在研究一个广泛的 各种疾病和人口统计群体，包括系统性红斑狼疮 红斑狼疮、骨关节炎、幼年性皮肌炎(JDMS)、 类风湿性关节炎和老年人。核心资源已被使用 高效，因为除了卓越的规模经济外 与EEHSR组件进行协调。认识到较新的 分析技术已经变得可用并被更多人接受，而且 这项建议代表了我们在临床上工作的扩展。 流行病学和卫生服务研究，这一提议的核心既是 更大，以支持更大的工作量和更广泛的使用 新的分析技术。由于执行委员会的 决定强调纵向和成本效益研究， 高级统计技术专家(广义估计 方程(GEE)、分类和回归树(CART)、 控制选择偏差的计量经济学方法(元分析)， 经济学和决策分析(随机树建模、连续- 风险效用评估)已被招募为核心联合调查员。 临床流行病学也已被正式纳入核心 结构。核心将支持以下四项EEHSR建议 赠款申请和JDMS登记处的供资活动以及 儿童纪念医院。它将继续为 MAMDC研究环境通过提供数据管理和 对从事关节炎相关研究人员的方法学帮助 研究。EEHSR/核心研究会议的机构和 增强了对卫生服务研究的可行性和支持 西北大学芝加哥校区将进一步提升 堆芯对环境的影响。

The Methodology and Data Management Core is critically important to the success of this MAMDC and its EEHSR Component in particular. The centralized availability of expertise in database and study form construction; data entry, monitoring, and retrieval, and the various analytic techniques used to test hypotheses and control for potential confounders are essential resources for all investigators. The Core has assisted educators, epidemiologists, and health services researchers from several divisions and departments in studying a wide variety of disease and demographic groups including systemic lupus erythematosus, osteoarthritis, juvenile dermatomyositis (JDMS), rheumatoid arthritis, and the elderly. Core resources have been used efficiently because of the economies of scale in addition to excellent coordination with the EEHSR component. Recognizing that newer analytic techniques have become available and more accepted and that this proposal represents an expansion of our work in clinical epidemiology and health services research, this proposed Core is both larger to support a greater volume of work and broader t utilize these new analytic techniques. As a result of the Executive Committee's decision to emphasize longitudinal and cost-effectiveness research, experts in advanced statistical techniques (generalized estimating equation (GEE), classification and regression trees (CART), econometric approaches to controlling selection bias, meta-analysis), economics, and decision analysis (stochastic tree modeling, continuous- risk utility assessment) have been recruited as Core co-investigators. Clinical Epidemiology has also been formally included within the Core structure. The Core will support the four EEHSR proposals in this grant application and the funded activities of the JDMS registry and Children's Memorial Hospital. It will continue to contribute to the MAMDC research environment by providing data management and methodologic assistance to investigators who engage in arthritis related research. The institution of a EEHSR/Core research conference and enhanced viability and support for health services research on Northwestern University's Chicago Campus will further heighten the Core's influence on the environment.