IMMUNOPATHOGENESIS OF CHRONIC CARDIAC GRAFT REJECTION

我们提出了一个综合的，多学科的研究计划的基础和 临床研究的总体目标是确定T 细胞在心脏移植慢性排斥反应发病机制中的作用， 开发预防慢性排斥反应的新方法， 受体的T细胞，对心脏移植物的耐受性。 这 将通过评估供体骨髓的输注是否 将预防或减轻人类移植物动脉硬化（GA）的严重程度 通过增加微嵌合体和诱导抗原- 具体宽容。 该计划项目是基于广泛的国家的最先进的专业知识， 微生物学和免疫学系的人类T细胞免疫学 天普大学医学院和一个广泛的，非常 Temple成功的临床成人心脏移植计划 大学医院，是美国最繁忙的医院。 七十 1994年在坦普尔大学进行了6例心脏移植手术 以理工科为重 截至1995年10月12日， 被执行。 该计划项目由研究项目组成： 1. T细胞在慢性排斥发病机制中的作用是 地址，2。 细胞因子在GA发展中的作用是 处理。 3. 第三个研究项目的目标是确定 供体骨髓的给药是否预防或减少了 心脏移植受者中GA的发生率和严重程度， 微嵌合体 这些互动研究得到了临床研究的支持。 移植核心和管理核心。 临床 移植核心包括与C博士的联盟安排。Ricordi 来自迈阿密大学医学院。

We propose an integrated, multi-disciplinary research program of basic and clinical research with an overall objective to determine the role of T cells in the pathogenesis of chronic rejection of cardiac allografts and to develop new approaches for prevention of chronic rejection by inducing, in athe T cells of the recipient, tolerance to the cardiac allograft. This will be accomplished by evaluating whether infusion of donor bone marrow will prevent or reduce the severity of graft arteriosclerosis (GA) in human cardiac allografts by increasing microchimerism and inducing antigen- specific tolerance. This Program Project is based on extensive stat e-of-the-art expertise in human T-cell immunology in the Department of Microbiology and Immunology of Temple University School of Medicine and on an extensive and very successful clinical adult heart transplantation program at Temple University Hospital, which is the busiest in the United States. Seventy six heart transplants were performed in 1994 at Temple University health Sciences. As of October 12, 1995 sixty five heart transplants have already been performed. This Program Project is comprised of Research Projects: 1. The role of T cells in the pathogenesis of chronic rejection is addressed, 2. The role of cytokines in the development of GA is addressed. 3. The objective of the third Research Project is to determine whether administration of donor bone marrow prevents or reduces the incidence and severity of GA in cardiac transplant recipients and increases microchimerism. These interactive studies are supported by a Clinical Transplantation Core and an Administrative Core. The Clinical Transplantation Core includes a consortium arrangement with Dr. C. Ricordi of the University of Miami, School of Medicine.