Immunogenetic Profiling for Risk of Primary Graft Dysfunction after Heart Transplantation
心脏移植后原发性移植物功能障碍风险的免疫遗传学分析
基本信息
- 批准号:10515335
- 负责人:
- 金额:$ 24.15万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-11-01 至 2024-10-31
- 项目状态:已结题
- 来源:
- 关键词:AcuteAffectAgonistAllograftingBiological MarkersBlood specimenCardiotoxicityCaringCell Surface ReceptorsCellsCellular biologyClinicalDataDendritic CellsEventFailureFunctional disorderFutureGene ExpressionGenesGoalsHeart TransplantationHeart failureHourHumanImmuneImmunogeneticsImmunophenotypingImmunosuppressionIncidenceInfectionInflammatoryInfrastructureInterferonsIntubationMediatingMembrane ProteinsModelingMolecularMorbidity - disease rateMyelogenousMyocardial dysfunctionOrganOrgan PreservationOrgan ProcurementsOutcomePathway interactionsPatientsPeripheral Blood Mononuclear CellPersonsPhenotypePlasmaPopulationProductionProteinsProteomicsRiskRisk FactorsRoleSerumSignal TransductionSurfaceTLR9 geneTechniquesTestingTimeToll-like receptorsTransplant RecipientsTransplantationTransplanted Heart ComplicationUnited StatesValidationWorkbiomarker developmentblood-based biomarkercell free DNAcell typeclinical riskclinically relevantcohortcytokinedisorder riskgraft dysfunctionhemodynamicshigh riskhypoperfusioninfection riskischemic injurymortalitymortality risknovelnovel markerpatient biomarkersprecision medicineresponsesingle cell sequencingsingle-cell RNA sequencingspecific biomarkerstranscriptomicstransplant centers
项目摘要
Immunogenetic Profiling for Risk of Primary Graft Dysfunction after Heart Transplantation
For the approximately 250,000 people in the United States living with end-stage heart failure, heart
transplantation (HT) remains the gold standard therapy. Despite excellent long-term survival, early mortality
remains high as a result of infection, rejection, and primary graft dysfunction (PGD). PGD, in particular, is a
devastating complication of HT in which acute failure of the new allograft leads to hemodynamic instability and
end-organ hypoperfusion. Thus, we propose herein to build upon interesting preliminary data suggesting that
plasma levels of CLEC4C, a protein that serves as a cell surface receptor for plasmacytoid dendritic cells
(pDCs), are higher prior to transplant in patients who subsequently develop PGD after HT. Specifically, we will
integrate immune profiling, single cell sequencing of pDCs and PBMCs, and single cell proteomics in
isolated pDCs to test the hypothesis that pDCS are quantitatively and functionally enriched in HT
recipient who develop PGD. This study has the potential to identify clinically relevant biomarkers in the care
of HT recipients and may help to elucidate the underlying molecular mechanisms of PGD.
心脏移植术后原发性移植物功能障碍的免疫遗传学分析
对于美国大约25万患有终末期心力衰竭的人来说,
移植(HT)仍然是金标准疗法。尽管长期生存率很高,但早期死亡率
由于感染、排斥和原发性移植物功能障碍(PGD),PGD,特别是,
HT的毁灭性并发症,其中新同种异体移植物的急性失败导致血流动力学不稳定,
终末器官灌注不足因此,我们在此建议建立在有趣的初步数据基础上,
CLEC4C的血浆水平,CLEC4C是一种作为浆细胞样树突状细胞的细胞表面受体的蛋白质
在移植前,在HT后随后发展PGD的患者中,pDC(pDC)的表达更高。具体来说,我们将
整合免疫分析、pDC和PBMC单细胞测序以及单细胞蛋白质组学,
分离的pDC以检验pDCS在HT中定量和功能富集的假设
接受者发展PGD。这项研究有可能确定临床相关的生物标志物在护理
可能有助于阐明PGD的潜在分子机制。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Svati H. Shah其他文献
Brain‐derived neurotrophic factor rs6265 (Val66Met) polymorphism is associated with disease severity and incidence of cardiovascular events in a patient cohort
脑源性神经营养因子 rs6265 (Val66Met) 多态性与患者队列中疾病严重程度和心血管事件发生率相关
- DOI:
- 发表时间:
2017 - 期刊:
- 影响因子:4.8
- 作者:
Rong Jiang;M. Babyak;B. Brummett;E. Hauser;Svati H. Shah;R. Becker;I. Siegler;Abanish Singh;Carol Haynes;Megan Chryst;D. Craig;Redford B Williams - 通讯作者:
Redford B Williams
The Genetics of Thrombosis
血栓形成的遗传学
- DOI:
10.1007/978-1-60327-235-3_4 - 发表时间:
2010 - 期刊:
- 影响因子:3.3
- 作者:
Svati H. Shah;R. Becker - 通讯作者:
R. Becker
Insulin Growth Factor Phenotypes in Heart Failure with Preserved Ejection Fraction, an INSPIRE Registry and CATHGEN Study: IGF axis in HFpEF.
保留射血分数的心力衰竭中的胰岛素生长因子表型、INSPIRE 注册和 CATHGEN 研究:HFpEF 中的 IGF 轴。
- DOI:
- 发表时间:
2021 - 期刊:
- 影响因子:6
- 作者:
F. Haddad;J. A. Ataam;M. Amsallem;N. Cauwenberghs;T. Kuznetsova;Y. Rosenberg;R. Zamanian;I. Karakikes;B. Horne;J. Muhlestein;L. Kwee;Svati H. Shah;H. Maecker;S. Knight;K. Knowlton - 通讯作者:
K. Knowlton
Sequencing in over 50,000 cases identifies coding and structural variation underlying atrial fibrillation risk
对 5 万多例病例进行测序,确定了房颤风险背后的编码和结构变异
- DOI:
10.1038/s41588-025-02074-9 - 发表时间:
2025-03-06 - 期刊:
- 影响因子:29.000
- 作者:
Seung Hoan Choi;Sean J. Jurgens;Ling Xiao;Matthew C. Hill;Christopher M. Haggerty;Garðar Sveinbjörnsson;Valerie N. Morrill;Nicholas A. Marston;Lu-Chen Weng;James P. Pirruccello;David O. Arnar;Daniel Fannar Gudbjartsson;Helene Mantineo;Aenne S. von Falkenhausen;Andrea Natale;Arnljot Tveit;Bastiaan Geelhoed;Carolina Roselli;David R. Van Wagoner;Dawood Darbar;Doreen Haase;Elsayed Z. Soliman;Giovanni E. Davogustto;Goo Jun;Hugh Calkins;Jeffrey L. Anderson;Jennifer A. Brody;Jennifer L. Halford;John Barnard;John E. Hokanson;Jonathan D. Smith;Joshua C. Bis;Kendra Young;Linda S. B. Johnson;Lorenz Risch;Lorne J. Gula;Lydia Coulter Kwee;Mark D. Chaffin;Michael Kühne;Michael Preuss;Namrata Gupta;Navid A. Nafissi;Nicholas L. Smith;Peter M. Nilsson;Pim van der Harst;Quinn S. Wells;Renae L. Judy;Renate B. Schnabel;Renee Johnson;Roelof A. J. Smit;Stacey Gabriel;Stacey Knight;Tetsushi Furukawa;Thomas W. Blackwell;Victor Nauffal;Xin Wang;Yuan-I Min;Zachary T. Yoneda;Zachary W. M. Laksman;Connie R. Bezzina;Alvaro Alonso;Bruce M. Psaty;Christine M. Albert;Dan E. Arking;Dan M. Roden;Daniel I. Chasman;Daniel J. Rader;David Conen;David D. McManus;Diane Fatkin;Emelia J. Benjamin;Eric Boerwinkle;Gregory M. Marcus;Ingrid E. Christophersen;J. Gustav Smith;Jason D. Roberts;Laura M. Raffield;M. Benjamin Shoemaker;Michael H. Cho;Michael J. Cutler;Michiel Rienstra;Mina K. Chung;Morten S. Olesen;Moritz F. Sinner;Nona Sotoodehnia;Paulus Kirchhof;Ruth J. F. Loos;Saman Nazarian;Sanghamitra Mohanty;Scott M. Damrauer;Stefan Kaab;Susan R. Heckbert;Susan Redline;Svati H. Shah;Toshihiro Tanaka;Yusuke Ebana;Hilma Holm;Kari Stefansson;Christian T. Ruff;Marc S. Sabatine;Kathryn L. Lunetta;Steven A. Lubitz;Patrick T. Ellinor - 通讯作者:
Patrick T. Ellinor
Epigenetic profiling identifies novel genes for ascending aortic aneurysm formation with bicuspid aortic valves.
表观遗传分析识别了二叶式主动脉瓣升主动脉瘤形成的新基因。
- DOI:
- 发表时间:
2015 - 期刊:
- 影响因子:0.6
- 作者:
A. Shah;S. Gregory;D. Krupp;Sheng Feng;A. Dorogi;Carol Haynes;E. Grass;Shu;E. Hauser;W. Kraus;Svati H. Shah;G. Hughes - 通讯作者:
G. Hughes
Svati H. Shah的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Svati H. Shah', 18)}}的其他基金
Immunogenetic Profiling for Risk of Primary Graft Dysfunction after Heart Transplantation
心脏移植后原发性移植物功能障碍风险的免疫遗传学分析
- 批准号:
10391731 - 财政年份:2021
- 资助金额:
$ 24.15万 - 项目类别:
Inflammatory and Metabolic Biomarkers in Cardiovascular Complications with SARS-CoV-2
SARS-CoV-2 心血管并发症中的炎症和代谢生物标志物
- 批准号:
10303644 - 财政年份:2021
- 资助金额:
$ 24.15万 - 项目类别:
Inflammatory and Metabolic Biomarkers in Cardiovascular Complications with SARS-CoV-2
SARS-CoV-2 心血管并发症中的炎症和代谢生物标志物
- 批准号:
10426342 - 财政年份:2021
- 资助金额:
$ 24.15万 - 项目类别:
A Personalized Metabolomic Approach to Human Obesity and Weight Loss
针对人类肥胖和减肥的个性化代谢组学方法
- 批准号:
9196377 - 财政年份:2016
- 资助金额:
$ 24.15万 - 项目类别:
Metabolomic Quantitative Trait Locus (mQTL) Genetic Mapping in Human CVD
人类 CVD 代谢组学数量性状位点 (mQTL) 遗传图谱
- 批准号:
8150639 - 财政年份:2009
- 资助金额:
$ 24.15万 - 项目类别:
Metabolomic Quantitative Trait Locus (mQTL) Genetic Mapping in Human CVD
人类 CVD 代谢组学数量性状位点 (mQTL) 遗传图谱
- 批准号:
7894704 - 财政年份:2009
- 资助金额:
$ 24.15万 - 项目类别:
Metabolomic Quantitative Trait Locus (mQTL) Genetic Mapping in Human CVD
人类 CVD 代谢组学数量性状位点 (mQTL) 遗传图谱
- 批准号:
7636093 - 财政年份:2009
- 资助金额:
$ 24.15万 - 项目类别:
Metabolomic Quantitative Trait Locus (mQTL) Genetic Mapping in Human CVD
人类 CVD 代谢组学数量性状位点 (mQTL) 遗传图谱
- 批准号:
8470689 - 财政年份:2009
- 资助金额:
$ 24.15万 - 项目类别:
Metabolomic Quantitative Trait Locus (mQTL) Genetic Mapping in Human CVD
人类 CVD 代谢组学数量性状位点 (mQTL) 遗传图谱
- 批准号:
8318232 - 财政年份:2009
- 资助金额:
$ 24.15万 - 项目类别:
相似海外基金
How Does Particle Material Properties Insoluble and Partially Soluble Affect Sensory Perception Of Fat based Products
不溶性和部分可溶的颗粒材料特性如何影响脂肪基产品的感官知觉
- 批准号:
BB/Z514391/1 - 财政年份:2024
- 资助金额:
$ 24.15万 - 项目类别:
Training Grant
BRC-BIO: Establishing Astrangia poculata as a study system to understand how multi-partner symbiotic interactions affect pathogen response in cnidarians
BRC-BIO:建立 Astrangia poculata 作为研究系统,以了解多伙伴共生相互作用如何影响刺胞动物的病原体反应
- 批准号:
2312555 - 财政年份:2024
- 资助金额:
$ 24.15万 - 项目类别:
Standard Grant
RII Track-4:NSF: From the Ground Up to the Air Above Coastal Dunes: How Groundwater and Evaporation Affect the Mechanism of Wind Erosion
RII Track-4:NSF:从地面到沿海沙丘上方的空气:地下水和蒸发如何影响风蚀机制
- 批准号:
2327346 - 财政年份:2024
- 资助金额:
$ 24.15万 - 项目类别:
Standard Grant
Graduating in Austerity: Do Welfare Cuts Affect the Career Path of University Students?
紧缩毕业:福利削减会影响大学生的职业道路吗?
- 批准号:
ES/Z502595/1 - 财政年份:2024
- 资助金额:
$ 24.15万 - 项目类别:
Fellowship
感性個人差指標 Affect-X の構築とビスポークAIサービスの基盤確立
建立个人敏感度指数 Affect-X 并为定制人工智能服务奠定基础
- 批准号:
23K24936 - 财政年份:2024
- 资助金额:
$ 24.15万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Insecure lives and the policy disconnect: How multiple insecurities affect Levelling Up and what joined-up policy can do to help
不安全的生活和政策脱节:多种不安全因素如何影响升级以及联合政策可以提供哪些帮助
- 批准号:
ES/Z000149/1 - 财政年份:2024
- 资助金额:
$ 24.15万 - 项目类别:
Research Grant
How does metal binding affect the function of proteins targeted by a devastating pathogen of cereal crops?
金属结合如何影响谷类作物毁灭性病原体靶向的蛋白质的功能?
- 批准号:
2901648 - 财政年份:2024
- 资助金额:
$ 24.15万 - 项目类别:
Studentship
Investigating how double-negative T cells affect anti-leukemic and GvHD-inducing activities of conventional T cells
研究双阴性 T 细胞如何影响传统 T 细胞的抗白血病和 GvHD 诱导活性
- 批准号:
488039 - 财政年份:2023
- 资助金额:
$ 24.15万 - 项目类别:
Operating Grants
New Tendencies of French Film Theory: Representation, Body, Affect
法国电影理论新动向:再现、身体、情感
- 批准号:
23K00129 - 财政年份:2023
- 资助金额:
$ 24.15万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
The Protruding Void: Mystical Affect in Samuel Beckett's Prose
突出的虚空:塞缪尔·贝克特散文中的神秘影响
- 批准号:
2883985 - 财政年份:2023
- 资助金额:
$ 24.15万 - 项目类别:
Studentship