Identifying Common Mechanisms of Neurodegeneration in Alzheimer's Disease, Amyotrophic lateral sclerosis and Parkinson's Disease

该项目是为了支持由伦敦玛丽女王大学的麦考密克博士领导的NEURONODE联盟和旧金山格莱斯顿研究所的芬克贝纳博士的实验室之间的合作。两个小组都建议确定神经退行性疾病的共同机制。与的合作涉及模型、方法、调查工具和专业知识的交流。这种交流将有助于这两个群体实现他们的目标。我们将扩大我们的分析范围，以确定AD中涉及神经变性的疾病机制，并更好地了解细胞的应激反应是否有助于不同疾病的共同致病过程。他们将提供有关蛋白质翻译的变化如何影响疾病中蛋白质周转的关键信息。我们的联合研究将为细胞降解途径和细胞运输途径在神经退行性疾病中的作用提供见解。

This project is to support the initiation of a collaboration between the NEURONODE consortium, led by Dr. McCormick at Queen Mary University of London, and Dr. Finkbeiner's lab at the Gladstone Institute in San Francisco. Both groups propose to identify common mechanisms in neurodegenerative diseases. The collaboration with involved the exchange of models, methods, investigational tools, and expertise. This exchange will aid both groups in achieving their goals. We will expand our analysis to identify disease mechanisms involved neurodegeneration in AD and better understand if how the stress response of cells contribute to common pathogenic processes in the different diseases. They will provide critical information on how changes in protein translation may affect protein turnover in disease. Our joint studies will provide insights on the role of the cell degradation pathways and the cell trafficking pathways in neurodegenerative diseases.