REPOLARIZATION CHANGES ASSOCIATED WITH VENTRICULAR ARRHYTHMIAS AND SUDDEN DEATH

项目3是一个面向临床的检查复极变化 出现在室性心动过速和心室颤动之前。 实验将在犬和患者中进行。 项目3 包含三个子项目：项目3.1，复极变化 缺血性猝死前即刻：项目3.2，复极 持续性室性心动过速前即刻的变化;以及 项目3.3，复极变化作为ESVEM结果的预测因素 审判 这三个子项目由一个一般假设统一起来： 复极变化先于心室肌细胞的复极， 心律失常 在专题3.1中，我们将研究复极的性质和程度 QT间期反映的急性心肌梗死期间的变化 间隔、激活-恢复间隔和Q积分。 我们 将决定静息电位变化的程度， 负责QCQs积分的变更。 一种用于记录 将验证人的慢性复极化变化。 在项目3.2中，我们将测量复极变化， 患者持续性室性心动过速发作前即刻 使用霍尔特磁带自动分析入组ESVEM试验 录音. 在项目3.3中，我们将使用相同的功能和患者人群， 评估复极变异性的预后意义 持续时间，以及变化之间的关系。

Project 3 is a clinically oriented examination of repolarization changes that precede ventricular tachycardia and ventricular fibrillation. Experiments will be performed in both dogs and patients. Project 3 contains three subprojects: Project 3.1, Repolarization Changes Immediately Preceding Ischemic Sudden Death: Project 3.2, Repolarization Changes Immediately Preceding Sustained Ventricular Tachycardia; and Project 3.3, Repolarization Change as a Predictor of Outcome in the ESVEM Trial. The three subprojects are unified by a general hypothesis: Repolarization changes precede and may be causative of ventricular tachyarrhythmias. In Project 3.1 we will examine the nature and extent of repolarization changes during acute myocardial infarction as reflected by the QT interval, the activation-recovery interval and the QRST integral. We will determine the extent to which a change in resting potential is responsible for alteration in QRST integral. A system for recording repolarization changes chronically in man will be validated. In Project 3.2 we will measure repolarization changes occurring immediately before onset of sustained ventricular tachycardia in patients enrolled in the ESVEM Trial using an automated analysis of Holter tape recordings. In Project 3.3 we will use the same capability and patient population to evaluate the prognostic significance of variability of repolarization duration, and the relationship between change in that variability.