Development of Iron Complexes for the Treatment of FriedreichÍs Ataxia & the Role of Frataxin in Iron Metabolism

弗里德赖希共济失调（FA）是一种神经和心脏退行性疾病，在线粒体中有有毒铁（Fe）的积累。我们目前NHMRC资助的工作表明，铁在FA病理中起着重要作用。事实上，CIs分析了线粒体铁负载的机制，并在过去两年中在高影响力期刊上发表了8篇论文，其中3篇在PNAS USA发表。对这一过程的理解导致了FA药物的合理化设计

Friedreich's ataxia (FA) is a neuro- & cardio-degenerative disease where there is an accumulation of toxic iron (Fe) in the mitochondrion. Work from our current NHMRC grant showed iron plays a significant role in FA pathology In fact, the CIs dissected the mechanisms of mitochondrial iron-loading & have published 8 papers in high impact journals with 3 papers in PNAS USA in the last 2 yrs Understanding of this process has led to the design of rationalised drugs for FA This work in this Renewal could lead to novel therapies for FA