ROLE/PRODUCTION OF BIOLOGICALLY ACTIVE SECONDARY METABOLITES FROM MARINE ALGAE

几种加勒比海海藻的脂溶提取物 已经确定了具有生物活性的。高变异性 在这些次生代谢物的合成中已经得到证实。 目前对该化合物的合成和合成条件知之甚少。 控制或影响他们的生产。我们已隔离进实验室 以前发现的陶粒红藻的培养种类 具有抗菌活性。培养的植物已经被 证明可以产生具有金盏花环状特性的二十烷类化合物 哺乳动物的系统。这些红藻是潜在的重要来源 二十烷类化合物可用作研究生物化学物质，以加快我们的 了解它们在哺乳动物系统中扮演的生理角色。 这些化合物在生物体中所起的生理作用 生产它们几乎完全是未知的。主要目标是 在受控培养条件下确定这些物理和/或 控制或影响活性物质生产的化学因素 次生代谢物和通过实验室操作确定 二十烷类化合物在红藻中的生理作用(S)。 次要目标是确定哪些次生代谢物 负责抗生素的活性和化学特性 那些化合物。

Lipid soluble extracts of a number of Caribbean marine algae demonstrating biological activity have been identified. High variability in the synthesis of these secondary metabolites has been demonstrated. Presently little is known about the synthesis and conditions which control or influence their production. We have isolated into laboratory culture species of ceramialean red algae which have previously been shown to possess antimicrobial activities. Cultured plants have been demonstrated to produce eicosanoid compounds with autacoid properties in mammalian systems. These red algae are a potentially important source of eicosanoids which may be used as research biochemicals to expedite our understanding of the physiological roles they play in mammalian systems. The physiological role played by these compounds in the organisms that produce them are almost entirely unknown. Key objectives are to determine under controlled culture conditions those physical and/or chemical factors which control or influence the production of the active secondary metabolites and by laboratory manipulation determine the physiological role(s) played by eicosanoid compounds in a red algae. Secondary objectives are to determine which secondary metabolites are responsible for the antibiotic activity and to chemically characterize those compounds.