ACQUISITION OF A ROUTINE MASS SPECTROMETER

这是十个PI的联合提案（其中八个具有当前和/或 正在等待NIH的支持）从事化学合成的各个方面 涉及有机、有机金属和生物化合物。 九 教师都在波士顿学院化学系：一个是在 生物系。 我们的提议是购买一套舞蹈， 高通量，质谱仪（MS），可以帮助研究生 和博士后助理进行日常任务， 表征反应产物和监测反应结果。 在 目前波士顿学院唯一的质谱仪是GC/MS 其限于分子量低于500 amu的样品， 挥发性足以通过气相色谱（GC）柱， 这可以通过电子碰撞（EI）技术来检测。 GC/MS是 因此对大学里产生的大多数样本来说都是无用的。的 所提出的仪器是Micromass Platform II质谱仪系统 配备有HPLC/MS接口和直接插入探针， 采用电喷雾/大气压电离（ES/API）、快原子 电子轰击（FAB）、电子碰撞（EI）和化学电离（CI） 质量范围为2-4500 Da/e。拟议文书 将满足我们绝大多数的需求。 电离的多样性 能力将满足不同用户的各种需求 组，而不是冗余。 该仪器足够灵活， 可处理多种样品，足够耐用，使用方便 是一个高容量的主力，最少的停机时间。 此外，委员会认为， 尽管所请求的MS被分类为“低分辨率” 仪器，它将被配置为获得精确的质量测量， 满足期刊高分辨率（HRMS）出版标准。获得 所要求的工具将提高生产力，并为学生提供 和博士后研究员动手接触到一个最有价值的 可用的分析技术。

This is a joint proposal from ten PI's (eight with current and/or pending NIH support) engaged in various facets of chemical synthesis involving organic, organometallic, and biological compounds. Nine of the faculty are in the Boston College Chemistry Department: one is in the Biology Department. The proposal is for the purchase of a routine, high-throughput, mass spectrometer (MS) that can help graduate students and postdoctoral associates to carry out everyday tasks of characterizing reaction products and monitoring reaction outcomes. At present the only mass spectrometer anywhere at Boston College is a GC/MS that is limited to samples with a molecular weight under 500 amu that are volatile enough to go through a gas chromatography (GC) column and that can be detected by electron impact (EI) techniques. The GC/MS is thus useless for most of the samples generated at the University. The proposed instrument is a Micromass Platform II Mass Spectrometer System equipped with both an HPLC/MS interface and a direct insertion probe, with electrospray/atmospheric pressure ionization (ES/API), fast atom bombardment (FAB), electron impact (EI), and chemical ionization (CI) capabilities with a mass range of 2-4500 Da/e. The proposed instrument will address the vast majority of our needs. The variety of ionization capabilities will satisfy the various requirements of a diverse user group without being redundant. The instrument is flexible enough to handle many kinds of samples and sufficiently durable and user-friendly to be a high-capacity workhorse with minimal down time. Moreover, although the requested MS is classified as a "low resolution" instrument, it will be configured to obtain exact mass measurement that satisfy journal high resolution (HRMS) publication criteria. Access to the requested instrument will increase productivity and give students and postdoctoral fellows hands-on exposure to one of the most valuable analytical techniques available.