SYNTHESIS OF POLYMERS AS MIMICS FOR BIOLOGICAL MEMBRANES AND CHIRAL MOLECULES

我们努力的总体研究计划是开发聚合物材料 它们模仿生物系统。我们目前正专注于 基于非共价键的聚合物的研究进展 相互作用和/或电子转移过程。 这项工作的第一个目标将是发展和节约 制备光学活性乙烯基聚合物的可行方法或 螺旋正义选择性聚合。计算和实验 将以互补的方式使用技术来发展这一点 方法论。通过研究单体结构--全同立构倾向 合成的全同立构的聚合和构象稳定性 聚合物，我们希望发展这一方法学。光学上不贵 活性聚合物将在分子生物学、合成酶等领域中发挥作用 和可再生的不对称试剂。第二，我们打算进一步 MIEC嵌段共聚物作为生物传感器活性成分的研究进展 非共价法检测和定量氨基酸对映体 互动。我们还将评估和开发MIEC区块 用于生物电子转移膜的共聚物。这是意料之中的 这项工作将导致合成膜的制备 治疗目的。

The general research plan of our effort is to develop polymeric materials that mimic biological systems. We are currently concentrating on the development of polymers which function on the basis of noncovalent interactions and/or electron transfer processes. The first objective of the work will be to develop and economically feasible methodology for preparing optically active vinyl polymers or helix sense selective polymerization. Computational and experimental techniques will be used in a complementary fashion to develop this methodology. By studying monomer structure-tendency to isotactic polymerization and conformational stabilities of the resulting isotactic polymers, we expect to develop this methodology. Inexpensive optically active polymers will be useful in molecular biology, synthetic enzymes and regenerable asymmetric reagents. Secondly, we intent to further develop the MIEC block copolymers as the active component in biosensors to detect and quantify enantiomers of amino acids through noncovalent interactions. We will, also, evaluate and develop the MIEC block copolymers for biological electron transfer membranes. It is expected this work will result in the preparation of synthetic membranes for therapeutic purposes.