COORDINATE ACTIONS AND PLASTICITY OF PROPRIOCEPTIVE PATHWAYS

计划项目赠款的目标是发现 协调运动的结果是 脊髓中的肌肉骨骼系统和神经回路。这个 本项目的目的是研究本体感觉的作用。 肌间和关节间协调的调节途径 多方向运动。实验将在Free上进行 移动猫咪和去脑筋的准备。招聘的模式 作用于脚踝的关键输出元素，包括两块完整的肌肉 在正常动物的矢状面上可以观察到 平面运动和转弯运动。在终端实验中， 连接这些关键输出的本体感觉通路的组织 元素将在去大脑的状态下进行研究。本体感受性 来自这些输出元素的反馈，而不是电机输出，将是 由于自我神经再支配的过程而变得无效 这一程序对协调和反射组织的影响 已评估。反馈在协调姿势肌肉中的重要性 在猫的后肢将通过切断选定的肌腱进行测试 负重的肌肉。如果完整的肌肉有类似的动作但 不同的使用模式假定 肌腱切断，那么假说如果强大就会得到支持 肌肉间反射从完好的肌肉发展到完好的肌肉。这个 本计划项目拨款中建议在此处和其他地方进行的实验 旨在帮助修改和扩展当前的脊髓功能模型 在运动控制方面。这些进展将导致更全面的 运动障碍的诊断和新疗法。

The goal of the Program Project Grant is to discover the manner in which coordinated movement results from interactions between the musculoskeletal system and neural circuits in the spinal cord. The purpose of this project is to investigate the role of proprioceptive pathways in mediating intermuscular and interjoint coordination during multi-directional movements. Experiments will be performed on freely moving cats and decerebrate preparations. The patterns of recruitment of key output elements which act at the ankle, including both whole muscles and compartments, will be observed in normal animals during sagittal plane locomotion and turning movements. In terminal experiments, the organization of proprioceptive pathways interconnecting these key output elements will be investigated in the decerebrate state. Proprioceptive feedback from these output elements, but not motor output, will be rendered ineffective by the process of self-reinnervation, and the effects of this procedure on coordination and reflex organization evaluated. The importance of feedback in coordinating postural muscles in the cat hindlimb will be tested by severing the tendons of selected weight-bearing muscles. If intact muscles with similar actions but different patterns of usage assume the activity patterns of the tenotomized muscles, then the hypothesis will be supported if strong intermuscular reflexes develop from and to the intact muscles. The experiments proposed here and elsewhere in this Program Project Grant are intended to help revise and extend current models of spinal cord function in motor control. These advances will lead to more comprehensive diagnoses and new treatments for motor disorders.