PROSTAGLANDIN EXCRETION IN PREECLAMPSIA

前列腺素代谢紊乱目前被认为是一种 子痫前期发病的主要机制。多数 然而，之前对这一理论的研究只包括了 已经患上了临床显性疾病。为了调查 前列腺素异常是否先于先兆子痫的发病 利用储存的尿样设计了一项嵌套式病例对照研究 预期早在怀孕13周时就收集了妇女的数据 参与NICHD钙预防子痫前期试验 (CPEP)。在这项研究中，我们比较了尿液中 先兆子痫患者诊断前前列腺素和血栓素的变化 与正常孕妇相比，先兆子痫的发病率 孕龄。实验室分析已经完成，数据 分析正在进行中。

A disturbance of prostaglandin metabolism is currently believed to be one of the major mechanisms in the pathogenesis of preeclampsia. Most previous studies of this theory, however, have included only women who had already developed clinically overt disease. In order to investigate whether prostaglandin abnormalities precede the onset of preeclampsia, we have designed a nested case-control study using stored urine specimens prospectively collected as early as thirteen weeks gestation from women participating in the NICHD Trial of Calcium to Prevent Preeclampsia (CPEP). In this study, we are comparing the urinary excretion of prostaglandin and thromboxane in preeclampsic women before the diagnosis of preeclampsia to that in normal pregnant women at comparable gestational ages. The laboratory analyses have been completed and data analysis is ongoing.