Development of modified IGF-binding proteins as novel anti-cancer chemotherapeutics

我们建议通过联合使用一种蛋白质来隔离促进癌细胞对化疗抵抗的生长因子，从而提高当前抗癌治疗的有效性。我们的目标是改善对乳腺癌和结直肠癌的破坏，同时减少不良副作用。我们的体外数据显示了这种新型联合治疗的有效性，它是这些生长因子的天然载体蛋白的修饰形式。该申请寻求资金，以在体内验证概念，以便为临床试验吸引商业资金。

We propose to enhance the effectiveness of current anti-cancer treatments by co-administering a protein to sequester growth factors that promote the resistance of cancer cells to chemotherapy. We aim to achieve improved destruction of breast and colorectal cancers but with reduced adverse side effects. Our in vitro data show the effectiveness of this novel co-therapeutic which is a modified form of a natural carrier protein for these growth factors. This application seeks funding to enable proof of concept in vivo in order to attract commercial funding for clinical trials.