CORE--ANIMAL MODEL

这个核心的目的是在各个项目中提供一致的动物模型准备。这将是这个核心的责任，准备慢性动物模型的个别研究人员。这将减少准备工作的可变性，并将个别项目主任从创建这些准备工作的极端劳动密集型任务中解放出来，并照顾他们术后立即恢复的工作。各种动物模型将由康尼什博士或在他的指导下制作，康尼什博士在慢性动物准备方面拥有多年经验，并在这些特定的动物准备方面经验丰富。在动物被不同的调查人员使用之前，我们将由两名技术人员协助准备和照料它们。由这个核心制备的模型将是(1)大鼠心力衰竭(HF)的冠脉结扎模型，()兔心衰的起搏模型，(3)狗的心衰起搏模型。

The purpose of this Core is to provide a consistent preparation of animal models across the various projects. It will be the responsibility of this Core to prepare the chronic animal models for the individual investigators. This will reduce the variability of preparations and will release the individual project directors from the extremely labor intensive task of creating these preparations and care for their immediate post operative recovery. The various animal models will be prepared by or under the director of Dr. Cornish who has had many years of experience in the preparation of chronic animals and is experienced in these specific animal preparations. We will be assisted by two technicians in the preparation and care of the animals prior to their use by the various investigators. The models prepared by this core will be (1) the coronary ligation model of heart failure (HF) in the rat, () the pacing model of HF in the rabbit, and (3) the pacing model of HF in the dog.