NERVOUS CONTROL OF BLOOD PRESSURE

血压控制通过心血管系统的各种反射对血压的控制 系统已在低等动物中得到广泛研究。 结果 已经被推广到人类。有很好的证据表明，许多 已经在低等动物中研究过的反射， 灵长类动物，因此可能不适用于人。 在人体中进行的实验不允许分离受体系统， 因此需要作出一些可能不正确的假设。 本研究建议的目的是探讨 颈动脉，主动脉和心肺受体在控制 灵长类动物的心血管系统 由于这项研究将涉及 有意识的灵长类动物，结果不会被以下因素的影响所影响： 麻醉剂 它还将解决的具体问题， 非肿胀性出血和下体阴性技术， 正压选择性地影响心肺感受器。 在 为了更彻底地解决有关卸载的问题， 将进行心肺感受器、主动脉和颈动脉神经记录 在麻醉的猴子中进行非扩张性麻醉。 后 反射已经在有意识的灵长类动物中进行了研究， 将研究各种反射。 有一段时间，人们假设 动脉压力感受器反射机制的改变可能导致 神经介导的高血压 这项研究将有助于回答这一问题， 并帮助我们理解这些受体的可能参与， 在病理条件下。

The control of blood pressure by the various reflexes of the cardiovascular system has been extensively investigated in lower animals. The results have been generalized to man. There is good evidence that many of the reflexes that have been studied in lower animals are not the same in the primate and therefore probably not applicable to man. The work which has been done in man does not permit the isolation of the receptor systems and therefore requires some assumptions to be made which may not be correct. The objective of this research proposal is to examine the role of the carotid, aortic and the cardiopulmonary receptors in the control of the cardiovascular system in the primate. Since the study will involve the conscious primate the results will not be clouded by the effects of anesthetics. It will also address the question of the specificity of the techniques of nonhypotensive hemorrhage and lower body negative and positive pressure as selectively effecting cardiopulmonary receptors. In order to more thoroughly address the question concerning the unloading of cardiopulmonary receptors, aortic and carotid nerve recordings will be done in the anesthetized monkey during nonhypotensive hemorrhages. After the reflexes have been examined in the conscious primate the interaction of the various reflexes will be studied. For sometime, it has been postulated that alternations in the arterial baroreflex mechanisms could result in a neurally mediated hypertension. This study will help to answer that question and help us understand the possible involvement of these receptors in pathologic conditions.