Animal Models Core

动物模型核心的目的是为项目提供必要的慢性动物，并确保本PPG中各个项目的动物模型的一致性。这将消除准备工作的可变性，并将个别项目主管从极其劳动密集型的工作中解放出来，即创造慢性动物并照顾它们的术后立即恢复。该中心还将对心力衰竭或假手术前和期间的动物进行超声心动图评估。动物模型核心在这个PPG的过去10年里非常有效地工作。

The purpose of the Animal Models Core is to provide chronic animals necessary for the projects and insure consistency in animal models across the various projects in this PPG. This will eliminate the variability of preparations and will release the individual Project Directors from the extremely labor intensive task of creating chronic animals and caring for their immediate post operative recovery. The Core will also provide echocardiographic assessment on animals prior to and during the development of heart failure or sham time controls. The Animal Models Core has worked very effectively over the past 10 years of this PPG. Various animal models will be prepared by or under the supervision of Dr. Kurtis G. Cornish who has had many years of experience in the preparation of chronic animals and is experienced in these specific animal preparations. He will be assisted by three technicians in the preparation and care of animals prior to their use by the PPG investigators. The models prepared by this Core will be (1) the coronary ligation model of heart failure (HF) in the rat, and (2) the pacing model of HF in the rabbit. Assessment of the cardiac status of all animals is obtained echocardiographically. The Core is supported by two echocardiographs. Rabbit imaging is done on an Accuson Sequoia 5120 machine and rodent images are obtained on a Visual Sonics Vevo 770. Ms. Johnnie Hackley is primarily responsible for obtaining the data on the rats and rabbits prior to, during and after the induction of heart failure.