STOP- Successful Treatment Of Paranoia: Replacing harmful paranoid thoughts with better alternatives

偏执狂与几种精神健康状况有关，包括精神病，并导致工作、家庭和社会功能的痛苦和损害。最近的思维进步表明，如果一次只关注一个特定的症状，并试图治疗它，而不是试图一次性治疗整个疾病，治疗可能会更有效。这项研究建议开发和测试一种名为CBM-pa的偏执狂新疗法的移动应用版本。CBM-PA是一种自我管理的心理疗法，它是通过将对偏执狂偏见的基础研究与可以改变这些偏见的既定技术相结合而开发的。CBM-pa是计算机化的，涉及阅读可能被以偏执的方式解读的文本(例如，一个陌生人的凝视可能反映出有害的意图)。该疗法鼓励读者通过使用文字、任务和问题进行另一种解释(如凝视反映无害的好奇心)。已经制定了六届会议的版本，并完成了可行性研究，取得了可喜的成果。在这项研究的第一年，我们将通过添加6个新创建的会话，将CBM-pa开发为一个更易于访问和更吸引人的手机应用程序，名为Stop：Success Treatment of Parania。在2-4年内，我们将让患者在常规治疗的同时停止治疗，并将其与对照条件进行比较，后者患者只需阅读移动应用程序中的文本。这项研究使用了随机对照设计，患者从两个不同的英国网站招募。参与者将接受6个或12个疗程的Stop，我们将立即以及在3个月和6个月后评估临床症状。这些治疗数据将与参加控制条件(阅读应用程序中的文本)的类似人的数据进行比较，并在同一时间进行评估。这些数据将向我们显示，停止是否有任何有益的影响，如果有，它们会持续多久。我们还将更详细地衡量多少次治疗能产生足够的症状缓解，从而达到临床有用的程度。

Paranoia is linked to several mental health conditions, including psychosis and leads to distress and impairment in work, family and social functioning. Recent advances in thinking suggest that treatments might be more effective if they focus on one particular symptom at a time and try to treat that rather than trying to treat the whole disorder in one go. This study proposes to develop and test a mobile app version of a new therapy for paranoia called CBM-pa. CBM-pa is a self-administered psychological therapy that has been developed by combining basic research on biases in paranoia with established techniques that can change these biases. CBM-pa is computerised and involves reading text that could be interpreted in a paranoid way (such as the stare of a stranger which could reflect harmful intentions). The therapy encourages readers to make the alternative interpretation (such as the stare reflecting harmless curiosity) by using word tasks and questions. A six-session version has been developed and a feasibility study has been completed with promising results. In year 1 of this study we will develop CBM-pa into a more accessible and engaging 12- session app for mobile phones, called STOP: Successful Treatment of Paranoia, by adding 6 newly created sessions. In years 2-4 we will give patients STOP alongside their usual treatment and compare this with a control condition where patients simply read text in the mobile app instead. The study uses a randomised controlled design and patients are recruited from two different UK sites. Participants will receive either 6 or 12 sessions of STOP and we will measure clinical symptoms immediately and at 3 and 6 months later. These treatment data will be compared with data from similar people who take part in a control condition (reading text in the app) and are assessed at the same times. The data will show us whether there are any beneficial effects of STOP and, if so, how long they last. We will also measure in more detail exactly how many sessions produce enough symptom reduction to be clinically useful.