CO-CONNECT: COVID - Curated and Open aNalysis aNd rEsearCh plaTform

CoConnect是一个合作项目，有四个CO-PI：杰斐逊(邓迪)、谢赫(爱丁堡)、霍普金斯(Phe)和昆兰(诺丁汉)。当前的新冠肺炎疫情已在世界各地造成数十万人死亡、卫生系统严重紧张和经济受损。目前，有有限的证据表明，从新冠肺炎康复并携带抗体的人可以免受第二次感染，如果是这样的话，这种保护能持续多久。了解谁是免疫的对于保护易受感染的个人、安全地减少基于人群的干预和控制疾病传播至关重要。可以帮助我们回答这些关键问题的数据是由英国各地的一系列研究小组在临床初级和二级保健环境中收集的。由于这是一种新的疾病，抗体数据捕获的标准还处于初级阶段，因此一些需要回答的关键问题的细节没有得到系统的捕获。数据的碎片化格局意味着，公共卫生组织和研究人员可能很难找到并访问他们需要的高质量数据。我们将：-标准化英国各地的抗体数据收集-配置能够对来自多个来源的数据集进行可靠、快速、识别和安全分析的基础设施-回答有关对新冠肺炎的免疫力及其对患者预后的影响的关键问题。

CO-CONNECT is a collaborative project and it has four CO-PIs: Jefferson (Dundee), Sheikh (Edinburgh), Hopkins (PHE) and Quinlan (Nottingham).The current COVID-19 pandemic has caused hundreds of thousands of deaths, severely strained health systems and damaged economies across the world. At this time there is limited evidence that people who have recovered from COVID-19 and have antibodies are protected from a second infection and if so, how long that lasts. Understanding who is immune is vital to protect vulnerable individuals, to safely scale back population-based interventions and for managing disease transmission. The data which can help us to answer these key questions have been collected across the UK by a range of research groups and within clinical primary and secondary care settings. As this is a new disease, the standards for antibody data capture are in their infancy so some of the details need to answer the key questions are not being captured systematically. The fragmented landscape of data means that it can be challenging for public health groups and researchers to find and access the high-quality data they need at pace. We will: - Standardise antibody data collection across the UK - Configure an infrastructure which enables trustworthy, fast, de-identified, secure analysis of data sets from across multiple sources - Answer key questions about immunity to COVID-19 and the implications for patient outcomes.