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CONCURRENT RADIATION AND GEMCITABINE FOR UNRESECTABLE HEAD AND NECK TUMORS

CONCURRENT RADIATION AND GEMCITABINE FOR UNRESECTABLE HEAD AND NECK TUMORS
同步放疗和吉西他滨治疗不可切除的头颈部肿瘤
批准号：
6113404
负责人：
Avraham Eisbruch
金额：
$0.02万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-12-01 至 1999-11-30
来源：
https://reporter.nih.gov/project-details/6113404
关键词：
antineoplastics blood chemistry clinical research clinical trial phase I combination cancer therapy drug metabolism drug screening /evaluation gemcitabine head /neck neoplasm human subject human therapy evaluation neoplasm /cancer chemotherapy neoplasm /cancer radiation therapy

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中文摘要
翻译
这是一项I期研究，旨在为不可切除的头颈部肿瘤患者寻求最大耐受剂量的吉西他滨，同时接受标准疗程的放疗。 将测量吉西他滨的血浆水平和肿瘤掺入以及肿瘤核苷酸池，以更好地了解吉西他滨可增强体内放射抗肿瘤活性的机制。
英文摘要
This is a phase I study seeking the maximally tolerated dose of gemcitabine delivered concurrent with a standard course of radiation for patients with unresectable head and neck tumors. Plasma levels and tumor incorporation of gemcitabine, as well as tumor nucleotide pools will be measured in order to gain a better understanding of the mechanisms by which gemcitabine may enhance radiation antitumoral activity in vivo.
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INDIVIDUALIZING IMRT TREATMENT IN BRAIN AND HEAD/NECK CA
CONCURRENT RADIATION AND GEMCITABINE FOR UNRESECTABLE HEAD AND NECK TUMORS
QUALITY OF LIFE IN HEAD AND NECK CANCER
QUALITY OF LIFE IN HEAD AND NECK CANCER
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