课题基金 / 基金详情

FAMILIES WITH GENETIC SUSCEPTIBILITY TO BREAST CANCER

FAMILIES WITH GENETIC SUSCEPTIBILITY TO BREAST CANCER
有乳腺癌遗传易感性的家庭
批准号：
6297130
负责人：
SOFIA DIANA MERAJVER
金额：
$0.02万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-12-01 至 1999-11-30
来源：
https://reporter.nih.gov/project-details/6297130
关键词：
brca gene breast neoplasms cancer risk cell line clinical research family genetics gene expression gene mutation genetic susceptibility human genetic material tag human subject lymphocyte neoplasm /cancer genetics

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中文摘要
翻译
BRCA1是一种可能的肿瘤抑制基因，位于染色体17q21上，携带BRCA1胚系突变的女性一生中患乳腺癌和/或卵巢癌的风险为85%。BRCA1的分离可能会提供对乳腺癌生物学的洞察，并导致对乳腺癌遗传易感性的预测性测试。来自乳腺癌常染色体显性遗传家系的永生化淋巴细胞是我们鉴定BRCA1的重要试剂。
英文摘要
BRCA 1 is a putative tumor suppressor gene located on chromosome 17q21, conferring an 85% lifetime risk of developing breast and/or ovarian cancer on women carrying BRCA1 germline mutations. The isolation of BRCA1 will likely provide insight into the biology of breast cancer as well as lead to predictive testing for genetic susceptibility to breast cancer. Immortalized lymphocytes from families with apparent autosomal dominant transmission of breast cancer are essential reagents in our efforts to identify BRCA1.
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