课题基金 / 基金详情

MECHANISM UNDERLYING PARENTERAL INSULIN TREATMENT

MECHANISM UNDERLYING PARENTERAL INSULIN TREATMENT
肠外胰岛素治疗的潜在机制
批准号：
6113132
负责人：
JERRY P PALMER
金额：
$0.39万
依托单位：
UNIVERSITY OF WASHINGTON
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-12-01 至 1999-11-30
来源：
https://reporter.nih.gov/project-details/6113132
关键词：
clinical research disease /disorder proneness /risk hormone regulation /control mechanism hormone therapy human subject human therapy evaluation insulin insulin dependent diabetes mellitus intravenous administration pancreatic islet function

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中文摘要
翻译
DPT-1是一项多中心、随机、全国性的试验，旨在确定对高风险非糖尿病患者进行抗原治疗是否能预防随后的IDDM。胰岛素静脉注射4天，然后皮下注射随机分配到治疗组。待验证的基本假设是，通过对DPT-1中临床IDDM高风险受试者注射胰岛素来预防临床IDDM，至少部分是通过胰岛素抑制b细胞功能（β细胞休息）的代谢作用介导的。了解肠外胰岛素预防IDDM的机制将为将来开发出更好的预防方法提供基础。
英文摘要
The DPT-1 is a multi-centered, randomized, national trial designed to determine whether antigen based therapy of high risk nondiabetic individuals can prevent subsequent IDDM. Insulin is administered IV for 4 days and then subcutaneously to those randomized to the treatment arm. The underlying hypothesis to be tested is that protection against clinical IDDM achieved by parenteral administration of insulin to subjects at high risk of clinical IDDM in the DPT-1 is mediated, at least in part, by insulin's metabolic effect to inhibit b-cell function (beta cell rest). Understanding the mechanism whereby parenteral insulin prevents IDDM would provide the basis for improved methods of prevention to be developed in the future.
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Ancillary Study Proposal for The Restoring Insulin Secretion (RISE) Study: Autoimmune Mechanisms for the Progressive Decline of Beta cell Function in Type 2 Diabetes (T2D)
Ancillary Study Proposal for The Restoring Insulin Secretion (RISE) Study: Autoimmune Mechanisms for the Progressive Decline of Beta cell Function in Type 2 Diabetes (T2D)
Identification of Islet Proteins Stimulatory for T Cells from Diabetes Patients
  • 批准号：
    8217176
  • 项目类别：
  • 资助金额：
    $36.43万
  • 财政年份：
    2010
  • 负责人：
    JERRY P PALMER
  • 依托单位：
    UNIVERSITY OF WASHINGTON
Identification of Islet Proteins Stimulatory for T Cells from Diabetes Patients
  • 批准号：
    7780170
  • 项目类别：
  • 资助金额：
    $46.08万
  • 财政年份：
    2010
  • 负责人：
    JERRY P PALMER
  • 依托单位：
    UNIVERSITY OF WASHINGTON