课题基金 / 基金详情

SPLANCHNIC FATTY ACIDS & BLOOD PRESSURE

SPLANCHNIC FATTY ACIDS & BLOOD PRESSURE
内脏脂肪酸
批准号：
6263706
负责人：
ROGER J GREKIN
金额：
$0.02万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-12-01 至 1999-11-30
来源：
https://reporter.nih.gov/project-details/6263706
关键词：
blood pressure clinical research fatty acid biosynthesis human subject hypertension neurotransmitter biosynthesis norepinephrine splanchnic nerves

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中文摘要
翻译
该试点项目旨在确定拟议研究的可行性，为全面研究做准备。 从这项试点研究中获得的初步数据将被用作NIH申请的一部分。计划的研究旨在表征内脏脂肪蓄积、内脏脂肪酸产生和去甲肾上腺素动力学之间的关系。 基于我们实验室的动物研究，我们提出增加脂肪酸向肝脏的输送诱导肾上腺素能神经元反射性释放去甲肾上腺素。 如果这一假设被证明是正确的，就可以解释内脏脂肪堆积和高血压之间的关系。
英文摘要
This pilot project is designed to establish the feasibility of proposed studies in preparation for a full study. Preliminary data obtained from this pilot study will be used as part of an application to the NIH. The planned studies are designed to characterize the relationships between visceral fat accumulation, spanchnic fatty acid production and norepinephrine kinetics. Based on animal work in our laboratory, we have proposed that increased fatty acid delivery to the liver induces a reflex release of norepinephrine by adrenergic neurons. This hypothesis, if proven correct, could explain the relationship between visceral fat accumulation and hypertension.
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