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WHOLE LIVER RADIATION DOSE ESCALATION FOR INTRAHEPATIC CANCERS

WHOLE LIVER RADIATION DOSE ESCALATION FOR INTRAHEPATIC CANCERS
肝内癌的全肝脏辐射剂量递增
批准号：
6297007
负责人：
CORNELIUS J MCGINN
金额：
$0.02万
依托单位：
OREGON HEALTH & SCIENCE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-12-01 至 1999-11-30
来源：
https://reporter.nih.gov/project-details/6297007
关键词：
clinical research clinical trials human subject human therapy evaluation liver neoplasms neoplasm /cancer radiation therapy radiation therapy dosage radiobiology whole body irradiation dosage

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中文摘要
翻译
虽然辐射已被证明对治疗始于肝脏或扩散到肝脏的癌症有效，但其效用受到可安全耐受的低剂量的限制。剂量限制副作用被称为辐射引起的肝脏疾病（RILD）。该试验将评估全肝辐射剂量增加的可行性，使用血液稀释剂（肝素）可以预防RILD的发展，使用阿替普酶（一种血凝块溶解剂）可以减轻发生RILD的严重程度。这一策略已被成功用于治疗骨髓移植后出现的类似毒性。
英文摘要
Although radiation has proven efficacy in the treatment of cancers that started in or spread to the liver, its usefulness is limited by the low dose that can be safely tolerated. The dose limiting side effect is referred to as Radiation Induced Liver Disease (RILD). This trial will assess the feasibility of whole liver radiation dose escalation utilizing a blood thinning agent (heparin) which may prevent the development of RILD, and alteplase (a blood clot dissolving agent) to reduce the severity of RILD should it occur. This strategy has been used to successfully to treat a similar toxicity which occurs following bone marrow transplant.
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会议论文
WHOLE LIVER RADIATION DOSE ESCALATION TRIAL UTILIZING ETHYOL AMIFOSTINE
WHOLE LIVER RADIATION DOSE ESCALATION FOR INTRAHEPATIC CANCERS
LOW DOSE LIVER IRRADIATION WITH HEPATIC ARTERIAL CHEMOTHERAPY FOR CANCER
RADIATION DOSE ESCALATION FOR FOCAL LIVER CANCER
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