课题基金 / 基金详情

SPLANCHNIC FATTY ACIDS & BLOOD PRESSURE

SPLANCHNIC FATTY ACIDS & BLOOD PRESSURE
内脏脂肪酸
批准号：
6297063
负责人：
ROGER J GREKIN
金额：
$0.02万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-12-01 至 1999-11-30
来源：
https://reporter.nih.gov/project-details/6297063
关键词：
blood pressure clinical research fatty acid biosynthesis human subject hypertension neurotransmitter biosynthesis norepinephrine splanchnic nerves

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中文摘要
翻译
这一试点项目旨在确定拟议研究的可行性，为全面研究做准备。从这项初步研究中获得的初步数据将作为NIH申请的一部分。计划中的研究旨在描述内脏脂肪堆积、海绵状脂肪酸产生和去甲肾上腺素动力学之间的关系。基于我们实验室的动物工作，我们提出，增加对肝脏的脂肪酸输送会诱导肾上腺素能神经元反射性地释放去甲肾上腺素。如果这一假设被证明是正确的，它可以解释内脏脂肪堆积和高血压之间的关系。
英文摘要
This pilot project is designed to establish the feasibility of proposed studies in preparation for a full study. Preliminary data obtained from this pilot study will be used as part of an application to the NIH. The planned studies are designed to characterize the relationships between visceral fat accumulation, spanchnic fatty acid production and norepinephrine kinetics. Based on animal work in our laboratory, we have proposed that increased fatty acid delivery to the liver induces a reflex release of norepinephrine by adrenergic neurons. This hypothesis, if proven correct, could explain the relationship between visceral fat accumulation and hypertension.
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