EFFECT OF CISAPRIDE ON THE CORRECTED QT INTERVAL IN YOUNG PATIENTS

西沙必利是一种新的促动剂，可促进或恢复 通过胃肠道的运动，被广泛用于治疗 胃食道反流与其他胃肠道疾病 儿童的运动性。最近，西沙必利被认为与 心电图上校正的QT间期延长 室性心律失常(尖端扭矩)和危及生命的事件 少数孤立患者(1-3例)。此外，一名15岁的女孩 先天性QT间期延长综合征，心得安和普奈洛尔联合治疗效果良好 心室起搏，但曾患有严重缺氧性脑病 长QT间期综合征诊断前的损伤，过期 出乎意料的是，在开始西沙必利治疗几个月后。因为 已报道的西沙必利与延长 纠正QT间期和危及生命的心律失常，我们 建议检查西沙必利对校正QT间期的影响 在服用这种药物的年轻患者中。我们打算获得 对大约35名年轻受试者进行了心电图检查， 在西沙必利期间，如果可能并在临床允许的情况下，在西沙必利之后 行政管理。3次采样时所有12导联的QT间期 通过以下方式记录、测量和校正心率的间隔 Bazett公式，并用配对t检验进行比较。这个 这项研究的意义在于可能检测到潜在的 西沙必利对心脏复极的不良影响 可能导致危及生命的心律失常的心电图。这个 西派瑞特对校正QT的不良影响的检测 间期(即延长)可能会影响这两种药物的临床应用 广泛使用的药物，并可能有助于进一步 心肌复极和心肌梗死的机制探讨 室性心律失常。

Cisapride is a new prokinetic agent that facilitates or restores motility through the gastrointestinal tract and is widely used to treat gastroesophageal reflux and other disorders of gastrointestinal motility in children. Recently, cisapride has been associated with prolongation of corrected QT interval on the electrocardiogram, complex ventricular arrhythmias (torsade de pointes) and life-threatening events in a few isolated patients (1-3). In addition, a 15 year old girl with the congenital long QT syndrome, well controlled with propranolol and ventricular pacing, but who had sustained severe hypoxic encephalopathic injury prior to the diagnosis of the long QT syndrome, expired unexpectedly several months after beginning cisapride therapy. Because of this reported association between cisapride and lengthening of the corrected QT interval along with life-threatening arrhythmias, we propose to examine the effect of cisapride on the corrected QT interval in young patients taking this medication. We intend to obtain electrocardiograms (ECG) in approximately 35 young subjects before, during, and, if possible and clinically permissible, after cisapride administration. The QT interval in all 12 leads at the 3 sampling intervals will be recorded, measured, corrected for the heart rate by Bazett's formula, and compared using the paired t test. The significance of this study is the possibe detection of potentially adverse effects of cisapride on ventricular repolarization measured on the ECG that could be lead to life-threatening arrhythmias. The detection of such an adverse effect of cisparide on the corrected QT interval (i.e. prolongation) could impact both the clinical use of this widely employed medication and possibly contribute to further investigation into the mechanisms of ventricular repolarization and ventricular arhythmias.